An Open Source Patient Simulator for Design and Evaluation of Computer Based Multiple Drug Dosing Control for Anesthetic and Hemodynamic Variables

Ionescu, Clara M.; Neckebroek, Martine; Ghita, Mihaela; Copot, Dana

doi:10.1109/access.2021.3049880

Cited by 43 publications

(25 citation statements)

References 71 publications

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“…Several control algorithms can be designed and evaluated for multi-drug dosing optimization of general anesthesia management while maintaining hemodynamic stabilization, using the recently developed benchmark simulator [36]. The open-source patient simulator allows the user to change models or conditions, set values and add control algorithms, aiming constantly the balance of all variables within clinically safe intervals.…”

Section: Proposed Mimo Approach For Hybrid Control Of Ahsmentioning

confidence: 99%

“…Moreover, the challenge introduced by the usual time delay in the BIS output and in the model of the hemodynamic system can be simplified by the choices of the user. The simulator features embedded in the initial version and the open-loop results depicting the synergistic and antagonist reactions between drugs are presented in [36].…”

Section: Proposed Mimo Approach For Hybrid Control Of Ahsmentioning

confidence: 99%

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Perspectives on Hybrid Control of the Anesthesia-Hemodynamic System in the Pandemic Context

Ghita

Neckebroek

Copot

et al. 2021

2021 29th Mediterranean Conference on Control and Automation (MED)

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This paper provides a visionary perspective on human-machine collaboration in a medical cyber-physical system (MCPS) during the 2020 pandemic context. For the time being, medical specialists in the operating room (OR) or Intensive Care Units (ICU) face special responsibilities when the procedures involve a patient with an infectious disease (e.g., COVID-19) that can cause several complications. The added workload of the anesthesiologist can be diminished by the context-aware pervasive assistance in the decisionmaking process for maintaining the optimal anesthesia and hemodynamics of the patient. A self-aware control system, with feedback from patient's monitored parameters and several surgical/ICU contextual data, is able to adapt his action accordingly, increasing treatment accuracy. The three main parts of general anesthesia (neuromuscular blockade, hypnosis and analgesia) and the hemodynamics (cardiac output, blood pressure) are perused from a global objective viewpoint, while intersecting the anesthesiologist's action upon his request. The integrative anesthesiologist-in-the-loop cyber-physical system (CPS) is emerging as an intelligent solution for hybrid control of anesthesia's depth, instead of total autonomous closed-loop controllers. This paper aims to create awareness throughout the anesthesiologists about the usefulness of integrating automation and data exchange in their clinical practice for providing increased attention to alarming situations. Moreover, it proposes an opening horizon for multi-disciplinary research. Hence, the connection between clinical and engineering frameworks envisages significant patient safety.*Mihaela Ghita is holder of doctoral fellowship of the Research Foundation -Flanders (FWO) no. 1184220N. Dana Copot is holder of FWO postdoctoral fellowship no. 12X6819N. Maria Ghita is holder of doctoral scholarship of the Special Research Fund of Ghent University no. 01D15919.

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Section: Proposed Mimo Approach For Hybrid Control Of Ahsmentioning

confidence: 99%

Section: Proposed Mimo Approach For Hybrid Control Of Ahsmentioning

confidence: 99%

Perspectives on Hybrid Control of the Anesthesia-Hemodynamic System in the Pandemic Context

Ghita

Neckebroek

Copot

et al. 2021

2021 29th Mediterranean Conference on Control and Automation (MED)

Self Cite

View full text Add to dashboard Cite

show abstract

“…In particular, general anaesthesia process plays an important role in intensive care and in many surgical interventions with a significant potential to be supported by an automatic control system. The main goal of the anaesthesia process regulation is to assure the required level of analgesia, muscle relaxation and depth of hypnosis (DoH) through the administration of specific drugs [2,4,5].…”

Section: Introductionmentioning

confidence: 99%

Linear MPC for anesthesia process with external predictor

Pawłowski

Schiavo

Latronico

et al. 2022

Computers & Chemical Engineering

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“…The anesthesia process is under continuous development with the aim of improving safety and efficacy. In this context, automatic control systems are seen as a potential technological progress in the operating rooms [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Model predictive control using MISO approach for drug co-administration in anesthesia

Pawłowski

Schiavo²,

Latronico³

et al. 2022

Journal of Process Control

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An Open Source Patient Simulator for Design and Evaluation of Computer Based Multiple Drug Dosing Control for Anesthetic and Hemodynamic Variables

Cited by 43 publications

References 71 publications

Perspectives on Hybrid Control of the Anesthesia-Hemodynamic System in the Pandemic Context

Perspectives on Hybrid Control of the Anesthesia-Hemodynamic System in the Pandemic Context

Linear MPC for anesthesia process with external predictor

Model predictive control using MISO approach for drug co-administration in anesthesia

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