An open, parallel, randomized, comparative, multicenter investigation evaluating the efficacy and tolerability of Mepilex Ag versus silver sulfadiazine in the treatment of deep partial-thickness burn injuries

Tang, Haichao; Lv, Guozhong; Fu, Jinfeng; Niu, Xihua; Li, Yeyang; Zhang, Mei; Zhang, Guoʼan; Hu, Da-hai; Chen, Xiao; Jin, Lei; Qi, Hongyan; Xia, Zenan

doi:10.1097/ta.0000000000000620

Cited by 40 publications

(38 citation statements)

References 11 publications

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“…66 These characteristics were taken into consideration in the design of three RCTs ( The other two trials were multicentre studies that compared treatment of partial-thickness burn injuries with Mepilex Ag and silver sulphadiazine (SSD). In the RCT reported by Tang et al, 74 data from 153 patients were included in the analysis (Mepilex Ag, n=71; SSD, n=82). Although there was no significant difference in the healing rates of burns between the two groups, more burns healed in the Mepilex Ag group (n=13, 18%) compared with the SSD group (n=4, 5%; p=0.016).…”

Section: Burn Injuriesmentioning

confidence: 99%

“…74 Mepilex Ag and SSD were also compared in a multicentre trial by Silverstein et al 34 The American Burn Association/ children burn outcomes questionnaire, the short form (36) health survey and the EuroQol 5D health questionnaires were used to assess the consequences of burns, QoL and quality-adjusted life year (QALY) analysis. A total of 100 patients entered the study (Mepilex Ag, n=49; SSD, n=51).…”

Section: Silverstein Et Al (2011) 34mentioning

confidence: 99%

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Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Davies

McCarty

Hamberg³

2017

J Wound Care

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Phil Davies has more than 25 years of experience of working in healthcare-related industries. During that time, he has authored and contributed to numerous peer-reviewed journal articles and conference presentations (oral and poster) relating to wound care and other areas of healthcare. Phil was awarded a BSc (Hons) Medical Cell Biology and Biochemistry by the University of Liverpool (United Kingdom) in 1989.Sara McCarty was awarded her BSc (Hons) in biomedical sciences in 2008 by the University of Chester, UK. Since then, Sara has gained research experience in the field of wound healing. As a medical writer, she has also authored and contributed to a number of peer-reviewed journal articles and conference presentations. In 2014, she was awarded a PhD in the role and control of matrix metalloproteases in cutaneous wound healing.Kristina Hamberg has over 10 years of experience of working with the design and development of wound care products, particularly those with antimicrobial properties. During that time, she has become an expert within the areas of microbiology and test method development, as well as infection prevention. Kristina was awarded her MSc in food science in 1997 from the University of Kalmar, Sweden, and in 2002 she was awarded a PhD for microbiological evaluation of novel technologies for food preservation by Chalmers Technical University, Gothenburg, Sweden.How to cite this document: Davies, P., McCarty, S., Hamberg, K. Silver-containing foam dressings with Safetac: a review of the scientific and clinical data. J Wound Care 2017; 26: 6 (Suppl. 1), S1-S32. Conclusion S24 References S27Downloaded from magonlinelibrary.com by 054

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Section: Burn Injuriesmentioning

confidence: 99%

Section: Silverstein Et Al (2011) 34mentioning

confidence: 99%

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Davies

McCarty

Hamberg³

2017

J Wound Care

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“…Silver‐impregnated foam dressing was reported in three RCTs, two of which were vs. SSD, and one vs. nanocrystalline silver . The patient population sizes ranged from 96 to 153, with one study (vs. nanocrystalline silver) in pediatric cases only .…”

Section: Resultsmentioning

confidence: 99%

“…Pain was reported by eight studies that compared the new antimicrobials with SSD/silver nitrate . Pain was assessed using either a 10‐point or 100‐point visual analog or face pain rating scale in small children in the included studies; however, reported results ranged from a week after treatment initiation to when the studies were completed at between three to six weeks.…”

Section: Resultsmentioning

confidence: 99%

Silver delivery approaches in the management of partial thickness burns: A systematic review and indirect treatment comparison

Nherera

Trueman

Roberts³

et al. 2017

Wound Repair Regeneration

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Silver‐containing products play an important role in the management of burn wound infections. We sought to compare the efficacy of commonly used silver delivery approaches including nanocrystalline silver, silver‐impregnated hydrofiber dressing, and silver‐impregnated foam dressing as the main products in the management of partial thickness burns. A systematic review was performed by searching PubMed, EMBASE, Cochrane, and other databases to identify relevant randomized controlled trials and observational studies. Due to the paucity of direct head‐to‐head trials, an indirect treatment comparison was performed. The use of nanocrystalline silver was associated with a statistically significant reduction in length of stay when compared to silver‐impregnated hydrofiber dressing (p = 0.027) and a shorter time to healing when compared to silver‐impregnated foam dressing (p = 0.0328). There were no statistically significant differences in infection rates and surgical procedures between nanocrystalline silver, silver‐impregnated hydrofiber dressing, and silver‐impregnated foam dressing; however, nanocrystalline silver was found to be the most beneficial for all the outcomes, including infection rates and surgical procedures, according to the Monte Carlo simulation method. In conclusion, current evidence from the published literature suggests that where the clinical and microbiological priority is to get in control of infection quickly it would seem prudent to use the most potent silver delivery system, which is nanocrystalline silver. Nanocrystalline silver may offer both clinical and economic benefits compared to alternative treatments in the management of patients with mixed burns that are at high risk of infection.

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“…46,[52][53][54] Silverbased dressings offer the antimicrobial benefits of topicals with less frequent dressing changes and better patient tolerability. [55][56][57] First introduced as a 10% ointment, mafenide is a topical sulfonamide with broad gram-positive and gram-negative activity, particularly Pseudomonas spp. 58 Mafenide offers the added benefit of eschar penetration for deep burns.…”

Section: Prophylactic Antimicrobial Selection Topicalsmentioning

confidence: 99%

Rational Selection and Use of Antimicrobials in Patients with Burn Injuries

Hill

Sinclair

Hickerson

2017

Clinics in Plastic Surgery

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An open, parallel, randomized, comparative, multicenter investigation evaluating the efficacy and tolerability of Mepilex Ag versus silver sulfadiazine in the treatment of deep partial-thickness burn injuries

Abstract: Therapeutic study, level III.

Cited by 40 publications

References 11 publications

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Silver delivery approaches in the management of partial thickness burns: A systematic review and indirect treatment comparison

Rational Selection and Use of Antimicrobials in Patients with Burn Injuries

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