An Open, Parallel, Randomized, Comparative, Multicenter Study to Evaluate the Cost-Effectiveness, Performance, Tolerance, and Safety of a Silver-Containing Soft Silicone Foam Dressing (Intervention) vs Silver Sulfadiazine Cream

Silverstein, Paul; Heimbach, David M.; Meites, Herbert; Latenser, B.A.; Mozingo, D.W.; Mullins, Fred; Garner, W.L.; Turkowski, J. R.; Shupp, Jeffrey W.; Glat, Paul M.; Purdue, Gary F.

doi:10.1097/bcr.0b013e318236fe31

Cited by 83 publications

(59 citation statements)

References 19 publications

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“…This material readily adheres to intact dry skin, but will remain in situ on the surface of a moist wound or damaged surrounding skin without adhering to fragile tissue. 34 Consequently, these dressings can be applied and reapplied without damaging the wound or stripping the epidermis in the periwound region (even in critical situations when exudate starts to dry out), 35 and will also minimise pain and psychological stress at dressing change. 36 The gentle but effective seal that forms between the intact skin and a dressing with Safetac inhibits the movement of exudate from the wound onto the periwound skin, helping to prevent moisture-related damage, such as maceration, to this region.…”

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confidence: 99%

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Davies

McCarty

Hamberg³

2017

J Wound Care

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Phil Davies has more than 25 years of experience of working in healthcare-related industries. During that time, he has authored and contributed to numerous peer-reviewed journal articles and conference presentations (oral and poster) relating to wound care and other areas of healthcare. Phil was awarded a BSc (Hons) Medical Cell Biology and Biochemistry by the University of Liverpool (United Kingdom) in 1989.Sara McCarty was awarded her BSc (Hons) in biomedical sciences in 2008 by the University of Chester, UK. Since then, Sara has gained research experience in the field of wound healing. As a medical writer, she has also authored and contributed to a number of peer-reviewed journal articles and conference presentations. In 2014, she was awarded a PhD in the role and control of matrix metalloproteases in cutaneous wound healing.Kristina Hamberg has over 10 years of experience of working with the design and development of wound care products, particularly those with antimicrobial properties. During that time, she has become an expert within the areas of microbiology and test method development, as well as infection prevention. Kristina was awarded her MSc in food science in 1997 from the University of Kalmar, Sweden, and in 2002 she was awarded a PhD for microbiological evaluation of novel technologies for food preservation by Chalmers Technical University, Gothenburg, Sweden.How to cite this document: Davies, P., McCarty, S., Hamberg, K. Silver-containing foam dressings with Safetac: a review of the scientific and clinical data. J Wound Care 2017; 26: 6 (Suppl. 1), S1-S32. Conclusion S24 References S27Downloaded from magonlinelibrary.com by 054

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confidence: 99%

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Davies

McCarty

Hamberg³

2017

J Wound Care

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“…Furthermore, it is unclear if these findings are generalizable to humans whose burns generally have more exudate than porcine burns, which would reduce or prevent desiccation under the foam dressing. Indeed, a recent human study by Silverstein et al 18 concluded that the same silver-containing soft silicone foam dressing that was used in our study (Mepilex Ag) was as effective in the treatment of patients as standard care (SSD). In addition, the group of patients treated with the soft silicone foam dressing demonstrated decreased pain and lower costs associated with treatment.…”

Section: Limitationsmentioning

confidence: 99%

Topical Antibiotic Ointment Versus Silver-containing Foam Dressing for Second-degree Burns in Swine

et al. 2015

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Objectives: Second-degree burns are very common but their management is controversial. These burns may be treated with either topical antimicrobial agents or advanced occlusive dressings; however, there is no established treatment comparator for preclinical studies. This study was designed to determine which of two commonly used comparator therapies (a silver-containing advanced dressing or a topical antibiotic ointment) resulted in faster reepithelialization and less scarring. The hypothesis was that second-degree burns treated with a topical antimicrobial ointment would heal faster and with less scarring than those treated with a silver-containing occlusive foam dressing in a porcine model. Methods:Deep partial-thickness burns were created on the flanks of three anesthetized female domestic pigs (20 to 25 kg) using a 150-g aluminum bar preheated in 80°C water bath and applied to the skin for 20 seconds using a force of 2 kg. The burn eschars were excised 48 hours later with an electric dermatome set at a depth of 0.75 mm. The wound beds were treated with a thin layer of triple-antibiotic petrolatum-based ointment (changed three times weekly) or a silver-containing foam dressing (changed once weekly). Full-thickness punch biopsies were obtained at 9, 11, 14, 16, 18, and 21 days for determination of percentage complete wound reepithelialization and at 28 days for measurement of scar depth.Results: At all dressing changes the wounds treated with the topical antibiotic appeared moist, while those treated with the silver-based dressings appeared dry. At day 21 all wounds treated with the ointment were completely reepithelialized, while only 55% of those treated with the silver dressing were reepithelialized (p < 0.001). Scar depth at day 28 was also significantly less in wounds treated with the topical antibiotic ointment (4.3 mm vs. 5.1 mm, difference = 0.7 mm; 95% confidence interval [CI] = 0.1 to 1.4 mm). There was less scar contraction in wounds treated with the topical antibiotic compared with the silver-based dressing (mean AE SD = 25.0% AE 14.6% vs. 38.9% AE 16.9%, difference = 13.9%; 95% CI = 5.7% to 22.0%).Conclusions: In this model of excised deep partial-thickness burns, a triple-antibiotic ointment enhanced reepithelialization and reduced scar depth and contraction compared with a silver-based foam dressing. This triple-antibiotic ointment should be considered as a control for studies evaluating novel topical burn therapies.ACADEMIC EMERGENCY MEDICINE 2015;22:927-933 © 2015 by the Society for Academic Emergency Medicine S econd-degree (partial-thickness) burns are very common, but their management is controversial. These burns are usually treated with either a topical antimicrobial cream or ointment or one of many advanced, silver-containing occlusive dressings. Over the past decade a large number of advanced burn dressings have been introduced into the marketplace. Many of these dressings contain silver due to its antimi-

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“…Such dressings are also made to be left on the burn wound and changed every 3 to 5 days or more often if soiled. 19 The dressing is lifted off of the burn wound to enable wound assessment for healing or infection as needed and then placed back over the wound and re-secured in place with an outer dressing or adhesive. These types of dressings obviate the need for the more time-consuming and more frequent application of topical ointment over large burn wounds.…”

Section: Standard Management Of Traumatic Woundsmentioning

confidence: 99%

Management of Traumatic Wounds and a Novel Approach to Delivering Wound Care in Children

Bernabe

Desmarais

Keller

2014

Advances in Wound Care

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Significance:The costs and morbidity of pediatric traumatic wounds are not well known. The literature lacks a comprehensive review of the volume, management, and outcomes of children sustaining soft tissue injury. We briefly review the existing literature for traumatic wounds such as open fractures and burns. Such injuries require dedicated wound care and we propose a novel approach for more efficient and more effective delivery of dedicated pediatric wound care. Recent Advances: New pediatric literature is emerging regarding the longterm effects of wound care pain in traumatic injuries-especially burns. A variety of wound dressings and alternative management techniques exist and are geared toward reducing wound care pain. Our institution utilizes a unique model to provide adequate sedation and pain control through a dedicated pediatric wound care unit. We believe that this model reduces the cost of wound care by decreasing emergency department and operating room visits as well as hospital length of stay. Critical Issues: First, medical costs related to pediatric traumatic wound care are not insignificant. The need for adequate pain control and sedation in children with complex wounds is traditionally managed with operating room intervention. Afterward, added costs can be from a hospital stay for ongoing acute wound management. Second, morbidities of complex traumatic wounds are shown to be related to the acute wound care received. Future Directions: Further guidelines are needed to determine the most effective and efficient care of complex traumatic soft tissue injuries in the pediatric population. SCOPE AND SIGNIFICANCEAccording to the National Trauma Data Bank, 127,234 children were admitted to a hospital for trauma in 2012. 1 Trauma is well known to be the leading cause of morbidity and mortality in children. The number of soft tissue wounds in this population, though, is not well defined. Wounds result from blunt, penetrating, and thermal mechanisms and can pose management challenges. These management challenges include initial management of a complex wound; pain and sedation control for wound evaluation and care; ongoing delivery of wound care; and the psychological morbidity associated with traumatic wounds. TRANSLATIONAL RELEVANCEThe heightened awareness of medical cost and impact of hospitalization on the family of the injured child will drive the evolution of wound care to a more effective and efficient strategy. 2 With this strategy in mind, we have instituted a unique model at our institution for the delivery of pediatric wound care that is utilized in traumatic wounds. CLINICAL RELEVANCEBefore introducing this wound care model, we review in greater detail the types and current management of traumatic wounds with a focus on more complex injuries. We discuss the development of our novel approach to caring for these traumatic wounds. This model reduces the cost associated with the number of emergency department and operating room visits as well as the hospital length of stay for our pediatric patients....

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An Open, Parallel, Randomized, Comparative, Multicenter Study to Evaluate the Cost-Effectiveness, Performance, Tolerance, and Safety of a Silver-Containing Soft Silicone Foam Dressing (Intervention) vs Silver Sulfadiazine Cream

Cited by 83 publications

References 19 publications

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Silver-containing foam dressings with Safetac: a review of the scientific and clinical data

Topical Antibiotic Ointment Versus Silver-containing Foam Dressing for Second-degree Burns in Swine

Management of Traumatic Wounds and a Novel Approach to Delivering Wound Care in Children

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