An open, non‐randomised comparison of escitalopram and duloxetine for the treatment of subjects with Generalized Anxiety Disorder

Abstract

Implications for clinical practice are discussed.

A Systematic Review of Efficacy, Safety, and Tolerability of Duloxetine

“…TEAEs were measured and nausea, dry mouth, dizziness, and somnolence were reported as the most frequent AEs (Figure 2). One study reported suicidal ideation, although no statistical significance was found between duloxetine and placebo groups (69). Duloxetine was more effective, safe and tolerated than placebo or other antidepressants (escitalopram and venlafaxine) ( Table 1).…”

Duloxetine in treating generalized anxiety disorder in adults: A meta‐analysis of published randomized, double‐blind, placebo‐controlled trials

“…A total of 278 studies were initially identified through the electronic search. First pass screening eliminated, leaving 30 studies (Stahl et al ., ; Koponen et al ., , ; Allgulander et al ., , ; Hartford et al ., , ; Russell et al ., , ; Davidson et al ., ; De Berardis et al ., ; Hoschl and Svestka, ; Norman and Olver, ; Pollack et al ., ; Rynn et al ., ; Trivedi et al ., ; Katzman, ; Kornstein et al ., ; Nicolini et al ., ; Simon et al ., , ; Pangallo et al ., ; Wu et al ., , ; Bodkin et al ., ; Piero and Locati, ; Sheehan et al ., ; Karaiskos et al ., ; Mavranezouli et al ., ; Alaka et al ., ) were considered potentially relevant for further inspection. After screening the full text, seven randomized controlled trials (RCTs) (Hartford et al ., ; Koponen et al ., ; Davidson et al ., ; Rynn et al ., ; Nicolini et al ., ; Wu et al ., ; Alaka et al ., ) ( n = 2,674) were available for meta‐analyses.…”

An observational study comparing the efficacy of duloxetine and pregabalin in patients with generalized anxiety disorder

“…Ukoliko se porede rezultati prikazane studije sa rezltatima publikovanih kontrolisanih -duplo slepih, randomizovanih, multicentričnih kliničkih studija koje ispitivale efikasnost pregabalina kod pacijenata sa GAP uočava se da postoje značajne sličnosti. Naime, u većini navedenih studija došlo je do komparabilnog umanjenja skora na primenjenim instrumentima za procenu kliničkog stanja pacijenata [12][13][14] .…”