An open-label, multicentre, randomized comparative study of efficacy, safety and tolerability of the 5 plant - extract BNO 1012 in the Delayed Antibiotic Prescription Method in children, aged 6 to 11 years with acute viral and post-viral rhinosinusitis

Popovych, Vasyl I.; Beketova, Halyna V.; Koshel, I V; Tsodikova, O. A.; Kriuchko, Tetiana A.; Абатуров, А Е; Вакуленко, Л.І.; Gavrylenko, Iurii

doi:10.1016/j.amjoto.2020.102564

Cited by 11 publications

(2 citation statements)

References 12 publications

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“…Melzer et al в 2006 г. [3,[18][19][20] провели систематический обзор применения препарата растительного происхождения в лечении больных ОРС. Был проделан анализ 22 исследований, из них шесть контролируемых исследований включено в систематический обзор, а четыре из этих шести объединены в метаанализ.…”

Section: актуальное в оториноларингологииunclassified

Phytotherapy of acute and chronic rhinosinusitis from the position of evidence-based medicine

2022

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The article highlights the problem of using phytotherapy in the treatment of the most topical inflammatory diseases of the ENT organs, namely acute and chronic rhinosinusitis. Phytotherapy of ENT diseases has always attracted both doctors and patients. However, from the standpoint of evidence-based medicine there were a lot of questions about most herbal remedies due to the small number of reliable, well-controlled studies. This article presents the data of evidence-based studies on phytotherapy of acute and chronic rhinosinusitis. They allow us to speak about secretolytic, secretomotor, anti-inflammatory, anti-edema, moderate antibacterial and antiviral effects of phytopreparations. A common pharmacological property of plants included in phytopreparations is the ability to block the phase of exudation and reduce the permeability of the vascular wall. Phytotherapy is a good alternative method of treatment of patients with chronic rhinosinusitis (CRS). Data on the complex therapy of rhinosinusitis are given. Nevertheless, the safety and efficacy of phytotherapy for the treatment of patients with CRS are currently uncertain. The clinical guidelines of the Russian Ministry of Health 2021 on the treatment of acute rhinosinusitis (ARS) note the following: any patient with ARS can be prescribed herbal remedies with proven anti-inflammatory and mucolytic effects in the absence of contraindications to accelerate resolution of the disease symptoms. The results of works devoted to the use of preparations of plant origin for the treatment of patients with acute and chronic sinusitis allow to estimate them as rather effective in the complex treatment of this group of patients. However, further controlled studies are required to obtain additional data on the effectiveness of phytotherapy.

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Section: актуальное в оториноларингологииunclassified

Phytotherapy of acute and chronic rhinosinusitis from the position of evidence-based medicine

2022

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“…Indeed, the application of these vegetal species has been remarkedly investigated and largely used to combat drug-resistant bacteria and viruses, infectious diseases, cancer, and as central nervous system disorders, including alzheimer, parkinson e recurrent seizures (Huyan et al, 2016;Makaremi et al, 2021;Marshall, 2020;Veeresham, 2012;Vilasboas-Campos et al, 2020;Vyas et al, 2019;. In contrast to conventional therapies, these products have lesser side effects and higher tolerability, making these products a promising therapeutic alternative in the search for new antiepileptic drug options (Deivasigamani et al, 2021;Popovych et al, 2020;Verma et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Plant-based pharmacological alternatives in the seizure treatment: A patent review

Pina

Guimarães

Sampaio

et al. 2022

RSD

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Epilepsy, a neurologic condition associated with recurring seizures, affects around 70 million people worldwide and it is responsible for health costs. The current drug therapies used for treating epilepsy have low efficacy and many adverse side effects. In addition, drug resistance can also be found. The association of these factors considerably compromises the patient's pharmacotherapy care. Therefore, natural plant-derived products are promising therapeutic alternatives in the search for new curative options to treat epileptic seizures. Thus, the search was carried out at the patents database in the world, Espacenet, in January 2021 and compiled plant species (extracts, essential oils and isolated plant compounds) with a potential effect on the seizure, published between 2015 and 2020. In recent years, researchers and pharmaceutical companies have developed several methods for obtaining extracts, essential oils and purification of natural compounds, which have proven to be effective for the treatment of epileptic seizures in pre-clinical animal models. These findings hold potential promising for the treatment of epilepsy, especially for the management of drug-resistant, however, these reports are in their early stages and further studies need to be done for these compounds to be marketed.

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Herbal Medicines for Rhinosinusitis: A Systematic Review and Network Meta-analysis

Hoang

Seresirikachorn

Chitsuthipakorn

et al. 2023

Curr Allergy Asthma Rep

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An open-label, multicentre, randomized comparative study of efficacy, safety and tolerability of the 5 plant - extract BNO 1012 in the Delayed Antibiotic Prescription Method in children, aged 6 to 11 years with acute viral and post-viral rhinosinusitis

Cited by 11 publications

References 12 publications

Phytotherapy of acute and chronic rhinosinusitis from the position of evidence-based medicine

Phytotherapy of acute and chronic rhinosinusitis from the position of evidence-based medicine

Plant-based pharmacological alternatives in the seizure treatment: A patent review

Herbal Medicines for Rhinosinusitis: A Systematic Review and Network Meta-analysis

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An open-label, multicentre, randomized comparative study of efficacy, safety and tolerability of the 5 plant - extract BNO 1012 in the Delayed Antibiotic Prescription Method in children, aged 6 to 11 years with acute viral and post-viral rhinosinusitis

Cited by 11 publications

References 12 publications

Phytotherapy of acute and chronic rhinosinusitis from the position of evidence-based medicine

Phytotherapy of acute and chronic rhinosinusitis from the position of evidence-based medicine

Plant-based pharmacological alternatives in the seizure treatment: A patent review

Herbal Medicines for Rhinosinusitis: A Systematic Review and Network Meta-analysis

Contact Info

Product

Resources

About

An open-label, multicentre, randomized comparative study of efficacy, safety and tolerability of the 5 plant - extract BNO 1012 in the Delayed Antibiotic Prescription Method in children, aged 6 to 11 years with acute viral and post-viral rhinosinusitis