An open-label, fixed-dose study of bupropion effect on sexual function scores in women treated for breast cancer

Mathias, Clarissa; Mendes, Carlos Maurício Cardeal; Sena, Eduardo Pondé de; Moraes, Eduardo Dias de; Bastos, Claudilson; Braghiroli, Maria Ignez; Nuñez, Geila Ribeiro; Athanazio, Rodrigo Abensur; Alban, L.; Moore, Halle C. F.; Giglio, Auro del

doi:10.1093/annonc/mdl304

Cited by 50 publications

(28 citation statements)

References 21 publications

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“…Transdermal formulations of testosterone have been shown to increase libido in clinical studies of women with surgically induced menopause or healthy premenopausal women [66][67][68] As mood has an impact on sexual activity, antidepressants have been used to boost libido. The antidepressant venlafaxine, compared with placebo, was reported to improve libido in at least one clinical trial in breast cancer survivors [55].…”

Section: Sexual Dysfunction and Vaginal Drynessmentioning

confidence: 99%

Recognition and management of treatment-related side effects for breast cancer patients receiving adjuvant endocrine therapy

Cella

Fallowfield

2007

Breast Cancer Res Treat

247

231

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In postmenopausal women with hormone receptor-positive early-stage breast cancer, the use of aromatase inhibitors (AIs) to suppress estrogen is associated with improved clinical outcomes compared with tamoxifen therapy. Women receiving such endocrine therapy may experience treatment-related side effects that negatively affect health-related quality of life (QoL) and adherence to therapy. In published clinical trials and in clinical practice, adverse events (AEs) constitute the main reason for nonadherence to endocrine treatment. Serious AEs are sometimes resolved by switching to a different agent, whereas other side effects can often be managed to allow patients to remain on therapy without sacrificing QoL. Across all adjuvant endocrine trials, regardless of the treatment received, vasomotor symptoms such as hot flashes are the most common side effects. Other frequently reported side effects, such as vaginal discharge, vaginal dryness, dyspareunia, and arthralgia, vary in prevalence between tamoxifen and AIs. Here we provide an overview of reported AEs of adjuvant endocrine therapy, focusing on those that are amenable to pharmacologic or nonpharmacologic management without treatment discontinuation. Also highlighted are specific management strategies that may improve patient QoL and thereby optimize adherence to therapy, which in turn might improve patient outcomes.

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Section: Sexual Dysfunction and Vaginal Drynessmentioning

confidence: 99%

Recognition and management of treatment-related side effects for breast cancer patients receiving adjuvant endocrine therapy

Cella

Fallowfield

2007

Breast Cancer Res Treat

247

231

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“…In the original validation study with a sample of 58 clinically depressed adults and 38 healthy controls, the ASEX was observed to be internally consistent (Cronbach's alpha ¼ .91) and reliable (test-retest r ¼ .80), and to be a sensitive and specific predictor of sexual dysfunction (sensitivity ¼ 82%; specificity ¼ 90%) . The ASEX also has been observed to effectively measure change in the severity of sexual dysfunction over time (Davidson et al, 2004;Gelenberg et al, 2000;Goldstein et al, 2004;Mathias et al, 2006;Nurnberg et al, 2003;Soykan, 2004). For the present sample, Cronbach's alpha ¼ .87.…”

Section: Assessment Of Sexual Dysfunctionmentioning

confidence: 66%

Effects of aerobic exercise on sexual functioning in depressed adults

Hoffman

Babyak

Hill

et al. 2009

Mental Health and Physical Activity

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“…The ASEX scale has performed in many studies to measure five specific items identified as the core elements of sexual function: sexual drive, arousal, penile erection/vaginal lubrication, ability to reach orgasm, and satisfaction from orgasm [5,28,29]. The most important deficiency of ASEX scale is that dyspareunia is not taken into account in evaluation of the sexual functions [17].…”

Section: Discussionmentioning

confidence: 99%

Long-term changes in sexual functions following complicated pregnancies and deliveries

Özler

Evsen²,

Em³

et al. 2013

J Clin Exp Invest

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ÖZETAmaç: Bu çalışmanın amacı komplike gebelik ve doğu-mun cinsel fonksiyonlar üzerine olan etkilerini değerlen-dirmek ve cinsel fonksiyonları etkileyen olası risk faktör-lerini belirlenmek.Yöntemler: Çalışma grubunu öyküsünde ağır preeklampsi, plasenta previa totalis, dekolman plasenta, post partum atoni öyküsü olan oluşturdu. Kontrol grubu yaş, parite, doğum şekli, meslek, gelir düzeyi ve eğitim durumu eşleşen kadınlardan oluşuyordu. Hastaların tekrar hamile kalma korkusu ve son doğumdaki ölüm korkusu anketler ile ölçüldü. Cinsel fonksiyonları değerlendirmek için Arizona cinsel deneyim skalası kullanıldı. Komplike gebelik ve doğumu olan ve olmayan kadınların cinsel fonksiyonlarını karşılaştırdık.Bulgular: Son doğum esnasında görülen ölüm korkusu ve tekrar hamile korkusu çalışma grubunda anlamlı olarak daha yüksek olduğu gözlendi (p = 0,002 ve p < 0,001, sırasıyla). Çalışma ve kontrol grubunda cinsel işlev bozukluğu gönüllülük oranı sırasıyla % 55,1 ve % 38,7 (p = 0,081) tespit edildi. Son doğum esnasında yaşanan ölüm korkusu cinsel işlev bozukluğu için önemli bir risk faktörü olarak bulunmuştur (odds oranı [OR] = 1,653; 95% CI = 1,131-2,415; p=0,009).Sonuç: Sonuç olarak, komplike gebelik ve doğum öyküsü olan kadınlarda cinsel işlev bozukluğu oranı sağlıklı gebelik ve doğum öyküsü olan kadınlarla neredeyse eşitti. Son doğum esnasında görülen ölüm korkusunun cinsel işlev bozukluğu için en önemli risk faktörü olduğu bulunmuştur.Anahtar kelimeler: Ölüm korkusu, tekrar gebe kalma korkusu, komplike gebelik, komplike doğum, cinsel işlev bozukluğu ABSTRACT Objective: The aim of this study is to evaluate the effects of complicated pregnancy and delivery (P/D) on sexual functions and to determine possible risk factors that affect sexual functions. Methods:Women, who have the history of severe preeclampsia, placenta previa totalis, abruption placentae or postpartum uterine atonia, comprised the study group. The control group was comprised the women matched for age, parity, mode of delivery, vocation, the level of income and education status. Their fear of getting pregnant again and fear of death in the most recent delivery were measured by questionnaires. The Arizona Sexual Experience Scale was used to assess the sexual functions. We compared sexual functions of the women with and without suffering from complicated P/D. Results:Fear of death during the last delivery and fear of getting pregnant again were significantly more intense in the study group (p=0.002 and p<0.001, respectively). The rates of volunteers detected sexual dysfunction in the study and control groups were 55.1% and 38.7%, respectively (p=0.081). Fear of death during the last delivery was found to be significant risk factors for sexual dysfunction (odds ratio [OR] = 1.653; 95% CI = 1.131-2.415; p=0.009). Conclusion:In conclusion, sexual dysfunction rate of women with a history of complicated pregnancy and delivery, was almost equal that of women with a history of health pregnancy and delivery. Fear of death during the last delivery was found to be most ...

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An open-label, fixed-dose study of bupropion effect on sexual function scores in women treated for breast cancer

Abstract: In this non-controlled open trial bupropion 150 mg/daily was associated with improved sexual function in women receiving adjuvant systemic treatment for breast cancer.

Cited by 50 publications

References 21 publications

Recognition and management of treatment-related side effects for breast cancer patients receiving adjuvant endocrine therapy

Recognition and management of treatment-related side effects for breast cancer patients receiving adjuvant endocrine therapy

Effects of aerobic exercise on sexual functioning in depressed adults

Long-term changes in sexual functions following complicated pregnancies and deliveries

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