“…In studies comparing relative effectiveness of various antidepressant drugs [18,23,25,26,28,32], no single antidepressant drug has been shown to be more effective than the others for chronic pain. Some physicians have advocated the use of antidepressant drugs in combination with phenothiazines [20,22,59,73,76,78,82,83,88], antiepi leptic drugs [75], lithium [ 16], or minor tran quilizers [71], However, these assertions are based on case studies; the effectiveness of antidepressant drugs in combination with these other agents is presently not known. Given the potential for the development of tardive dyskinesia with long-term use of neu roleptic drugs, and the lack of superior effect of combination therapy over antidepressant agents alone, use of neuroleptic drugs in chronic pain patients should be limited.…”