An online, non-destructive method for simultaneously detecting chemical, biological, and physical properties of herbal injections using hyperspectral imaging with artificial intelligence

Alginate/pectin dressing with niosomal mangosteen extract for enhanced wound healing: evaluating skin irritation by structure-activity relationship

“…It utilizes a vertical rather than a horizontal optical path, creating a shorter light path than that of the UV spectrophotometer. This helps reduce detection errors [ 67 , 68 ]. A calibration curve was created by plotting a graph of absorbance versus ME concentration (0.05–0.5 mg/mL) (Figures 1 B and 1C).…”

Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses

“… Category Technique Response Application Ref. Biological-chemical-coupling technology DART-MS-enzyme Chemical components and biological activities Danshen injection 61 ABTS ± CE Major antioxidants in injection Shuxuening injection 62 Metabolomics-chemometrics Bioactive-chemical quality marker combination Pollen of T. orientalis 63 Biosensors for PAT Enzyme based SPR Acceptable therapeutic monitoring Bromocriptine 64 HF-AS Lipase-binding ligands Lotus leaf extracts 65 TPE-fluorescent probe Monitor ACE activity Tongmaiyangxin pill 66 FRET fluorescent acceptor Patulin and zearalenone Extracts of TCM 67 Aptamer biosensor Rapid detection of pathogenic E. coli Licorice extracts 68 Protein chip for target enzyme PAD Hypoglycemic and xanthine oxidase inhibitory activity Mulberry, lotus and Salvia miltiorrhiza extracts 69 , 70 , 71 Dual-channel microfluidic chip Multiple biomarker assay Qishen Yiqi Pill 72 Biological soft sensing technology HSI-AI-CNN Physical, chemical and biological properties Shuxuening injection 73 NIR-machine learning Chemical compounds and anti-inflammatory activity Chrysanthemum extracts 74 …”

“…Taking Shuxuening injection as an example, Zhong et al. 73 used hyperspectral imaging (HSI) combined with artificial intelligence (AI) as a biological soft sensing technology to simultaneously monitor physical properties, chemical components, and biological activities of the injection in a non-destructive manner. The detection of chemical components in drugs often requires analytical equipment such as high-performance liquid chromatography (HPLC).…”

Pixel-Level Recognition of Trace Mycotoxins in Red Ginseng Based on Hyperspectral Imaging Combined with 1DCNN-Residual-BiLSTM-Attention Model

“…In recent years, with the development of deep-learning algorithms, they have been widely applied in the field of HSI [ 22 , 23 , 24 , 25 , 26 ]. Deep learning has also been used for the detection of aflatoxin in HSI images in agriculture.…”