An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways

Lv, Meng; Zhang, X; Jia, Haibo; Li, D; Zhang, B; Zhang, H; Miao, Hong; Jiang, Tao; Jiang, Qian; Lu, Jin; Huang, Xiao‐Jun; Huang, Bo

doi:10.1038/leu.2011.273

Cited by 159 publications

(149 citation statements)

References 50 publications

(61 reference statements)

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“…miRNAs target numerous genes, including HIF, mTOR, VEGF and VHL, through translational inhibition or the induction of mRNA degradation, which suggests that miRNAs function as important factors in RCC initiation and development (36,37). Previous studies have reported that miR-142-3p is dysregulated in various types of cancer (22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33), and may therefore function as a biomarker. The expression of miR-142-3p in RCC has not yet been validated by qPCR.…”

Section: Discussionmentioning

confidence: 99%

“…Previous microarray chip studies have demonstrated that miR-142-3p is overexpressed in RCC tissues compared with adjacent normal or benign kidney tissues (18)(19)(20)(21). It has also been reported that miR-142-3p is dysregulated in malignancies of the breast (22), thyroid (23), liver (24), stomach (25), lung (26), blood (27,28), colorectum (29), testes (30), esophagus (31), head and neck (32), and bone (33). The present study establishes the oncogenic role of miR-142-3p in RCC, demonstrating how it regulates cell migration, proliferation and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

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Oncogenic microRNA-142-3p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma

Chen

Jin

et al. 2015

Oncology Letters

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Abstract. MicroRNAs (miRNAs/miRs) serve an important role in the regulation of carcinogenic pathways. RCC is the most prevalent kidney cancer that occurs in adults. miRNAs have gained increasing attention due to their association with RCC tumorigenesis, serving as biomarkers for early detection and progression monitoring, and as potential targets for molecular therapy. Upregulation of miRNA-142-3p has been previously identified in RCC tissues by microarray profile, however, its expression and function in RCC have not yet been validated. In the present study, quantitative polymerase chain reaction was performed to quantify the relative expression of miR-142-3p in 53 paired RCC and adjacent normal tissues. Furthermore, wound healing, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and flow cytometry assays were performed to analyze the impacts of miR-142-3p on cellular migration, proliferation and apoptosis. The results demonstrated that miR-142-3p was significantly upregulated in RCC tissues compared with adjacent normal tissues. Downregulation of miR-142-3p, induced by chemically synthesized miR-142-3p inhibitor, significantly suppressed cell migration and proliferation, and promoted cell apoptosis in 786-O and ACHN cells, supporting the theory that miR-142-3p may function as an oncogene in RCC. The potential clinical significance of miR-142-3p, as a biomarker and therapeutic target, provides rationale for further investigation into the miR-142-3p-mediated molecular pathway and how it is associated with RCC development.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oncogenic microRNA-142-3p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma

Chen

Jin

et al. 2015

Oncology Letters

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“…We observed that the expression levels of miR-142-3p were significantly increased and were associated with clinicopathological features [21]. Recent studies have reported that miR-142-3p, which is located at chromosome 17q22, is important in the tumorigenesis of human T-cell acute lymphoblastic leukemia (T-ALL) [22], hepatocellular carcinoma [23] and esophageal squamous cell carcinoma [24]. However, the function of miR-142-3p in colorectal cancer is largely unknown.…”

mentioning

confidence: 86%

“…For instance, it was reported that high expression levels of miR-21 were significantly correlated with lymph node metastasis, advanced clinical stage, and poor prognosis in patients with breast cancer [29]. MiR-142-3p was recently identified as an oncogenic mi-RNA in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting the glucocorticoid receptor-a and the cAMP/PKA pathways [22]. Wu et al [23] demonstrated that miR-142-3p directly and negatively regulates RAC1 in HCC cells, and suppresses the migration and invasion of hepatocellular carcinoma cells.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-142-3p is frequently upregulated in colorectal cancer and may be involved in the regulation of cell proliferation

et al. 2013

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“…miRNAs play crucial roles in a broad range of physiological and pathological processes, including the processes of normal hematopoiesis and hematopoietic malignancies progression (7)(8)(9). Simultaneously, growing evidences have indicated that exposure to hazardous environmental factors may significantly disrupt miRNA expression patterns (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Analysis of plasma microRNA expression profiles in a Chinese population occupationally exposed to benzene and in a population with chronic benzene poisoning

Liu¹,

Chen

Bian

et al. 2016

J. Thorac. Dis.

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Background: Circulating microRNA (miRNA) has attractive interests as a non-invasive biomarker of physiological and pathological conditions. Our study aimed to investigate the potential effects of chronic benzene poisoning (CBP) and benzene exposure on miRNA expression, and identify CBP-related miRNAs. Methods:In the discovery stage, we used a microarray assay to detect the miRNA expression profiles among pooled plasma samples from ten CBP patients, ten healthy benzene-exposed individuals and ten nonbenzene exposed individuals. Subsequently, we conducted an expanded validation of six candidate miRNAs in 27 CBP patients-low blood counts, 54 healthy benzene-exposed individuals and 54 non-exposed individuals.Moreover, we predicted the biological functions of putative target genes using a Gene Ontology (GO) function enrichment analysis and KEGG pathway analysis.Results: In the discovery stage, compared with non-exposures, 36 and 12 miRNAs demonstrated at least a 1.0-fold differential expression in the CBP patients and the benzene exposures, respectively. And compared with benzene exposures, 58 miRNAs demonstrated at least a 1.0-fold differential expression in the CBP patients. In the expanded validation stage, compared with non-exposures as well as exposures, miR-24-3p and miR-221-3p were significantly up-regulated (1.99-and 2.06-fold for miR-24-3p, 2.19-and 3.93-fold for miR-221-3p, P<0.01) while miR-122-5p and miR-638 were significantly down-regulated (−3.45-and −2.60-fold for miR-122-5p, −1.82-and −3.20-fold for miR-638, P<0.001) in the CBP patients; compared with non-exposures, the plasma level of miR-638 was significantly up-regulated (1.38-fold, P<0.01) while the plasma levels miR-122-5p and miR-221-3p were significantly down-regulated (−0.85-and −1.74-fold, P<0.01) in the exposures, which were consistent with the results of microarray analysis. Conclusions:The four indicated plasma miRNAs may be biomarkers of indicating responses to benzene exposure. Further studies are warranted to verify our findings with a large sample and to confirm the underlying mechanisms.

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An oncogenic role of miR-142-3p in human T-cell acute lymphoblastic leukemia (T-ALL) by targeting glucocorticoid receptor-α and cAMP/PKA pathways

Cited by 159 publications

References 50 publications

Oncogenic microRNA-142-3p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma

Oncogenic microRNA-142-3p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma

MicroRNA-142-3p is frequently upregulated in colorectal cancer and may be involved in the regulation of cell proliferation

Analysis of plasma microRNA expression profiles in a Chinese population occupationally exposed to benzene and in a population with chronic benzene poisoning

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