An on-chip magnetic bead separator using spiral electromagnets with semi-encapsulated permalloy

Choi, Jin‐Woo; Liakopoulos, T.M.; Ahn, Chong H.

doi:10.1016/s0956-5663(01)00154-3

Cited by 134 publications

(76 citation statements)

References 7 publications

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“…For example, Choi et al have developed a technology to separate the magnetic beads in a micro-channel by electromagnet [4]. We may as well be able to control the beads in the module in combination with this method.…”

Section: Resultsmentioning

confidence: 99%

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A Lab-on-a-Chip Module for Bead Separation in DNA-Based Concept Learning

Lim

Jang²,

Ha³

et al. 2004

DNA Computing

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Abstract. Affinity separation with magnetic beads is an important and widely used technique for DNA computing. We have designed and implemented an experimental lab-on-a-chip module for affinity-bead separation for DNA-based concept learning. Magnetic beads with DNA-probe sequences immobilized on their surface were used to select target strands, and these beads are restrained in the channel by a permanent magnet on top of the module. The separation process consists of two steps, i.e. hybridization and denaturation. We confirmed the separation process by a mixed solution that contains FITC modified strands, and measured the yield by UV spectrophotometer. The experimental results demonstrate a successful separation of the mixed DNA.

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Section: Resultsmentioning

confidence: 99%

“…In addition, we are able to diminish the factors of errors inherent in DNA computing. Some examples for this technology can be found in [4,5,9,11,12].…”

Section: Introductionmentioning

confidence: 99%

A Lab-on-a-Chip Module for Bead Separation in DNA-Based Concept Learning

Lim

Jang²,

Ha³

et al. 2004

DNA Computing

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“…Active elements are primarily electromagnets that consume energy in addition to requiring complex microfabrication processes for their creation [13][14][15]. An advantage of electromagnets is that they can be switched on and off easily.…”

Section: Introductionmentioning

confidence: 99%

Microdevice for continuous flow magnetic separation for bioengineering applications

Khashan

Dagher

Alazzam

et al. 2017

J. Micromech. Microeng.

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A novel continuous flow microfluidic device, integrated with soft-magnetic wire (permalloy), is fabricated and tested for magnetophoresis based separation. The flow-invasive permalloy wire, magnetized using an external bias field, is positioned perpendicular to the external magnetic field and with its length traversing the introduced sample flow. The microfluidic device is realized in PDMS; the mold for PDMS microstructures is cut out of Plexiglas® sheets with controllable dimensions. Microfluidic devices with microchannel height ranging between 0.5 mm and 2 mm are fabricated. Experiments are carried out with and without sheath flow; with sheath flow the microparticles are focused at the center of the microchannel. When focusing is not employed, the microdevice can exhibit a complete separation (or filtration) with the introduction of the sample at rates lower than a maximum threshold. However, this complete separation is attributed to the fact that part of the particles, once they approach the repulsive field of the wire, will find their way into the attractive region of the wire while the remaining will be indefinitely trapped at the channel walls. On the other hand, when the focused sample is flowing at the same rate but alongside an appropriate sheath flow, the complete separation can be achieved with all (initially repelled) particles being captured on the attractive region of the wire itself. This microdevice design is well suited for purification, enrichment, and detection of microparticles in lab-on-a-chip devices due to its ability to handle high throughput without compromising capture efficiency while exhibiting excellent reliability and flexibility.

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“…The high-gradient magnetic field has been widely used in high-gradient magnetic separation (e.g., beneficiation of minerals) [19,20], micro-fluidic devices [21], biomedicine research (e.g., microchip technology for cell separations [22,23] and cell manipulations [24], as well as drug delivery by nanomagnetic particles [3,4]), wastewater treatment technology [25,26], chemical research (e.g., a high gradient magnetic field that can greatly influence chemical reaction rate [27]), the new generation of materials [28] and so on. Traditionally people obtain a gradient magnetic field simply by using an active magnet, which is an active device and limited by the heat effect.…”

Section: Introductionmentioning

confidence: 99%

“…Thus (B · ∇)B can be amplified, which means the magnetic force will be greatly enhanced passively. This will improve the recent technologies based on gradient magnetic force [19][20][21][22][23][24]. However, the material requirement of that DC magnetic compressor is very complex (inhomogeneous anisotropic magnetic materials are required), which means it is hard to realize it experimentally.…”

Section: Introductionmentioning

confidence: 99%

Transformation Inside a Null-Space Region and a Dc Magnetic Funnel for Achieving an Enhanced Magnetic Flux With a Large Gradient

Sun¹,

He²

2014

PIER

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Abstract-The idea of transformation inside a null-space region is introduced for the first time, and used to design a novel DC magnetic compressor that concentrates DC magnetic flux greatly and behaves as a DC magnetic funnel. The proposed device can be used as a passive DC magnetic lens to achieve an enhanced DC magnetic field (e.g., 7.9 times or more depending on the size and other parameters of the compressor) with a large gradient (e.g., 450 T/m or more) in free space. After some theoretical approximation, the proposed device can be easily constructed by using a combination of superconductors and ferromagnetic materials. Numerical simulations are given to verify the performance of our device. The proposed method (use a null-space region as the reference space) can be extended to reduce the material requirement when designing other devices with transformation optics.

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An on-chip magnetic bead separator using spiral electromagnets with semi-encapsulated permalloy

Cited by 134 publications

References 7 publications

A Lab-on-a-Chip Module for Bead Separation in DNA-Based Concept Learning

A Lab-on-a-Chip Module for Bead Separation in DNA-Based Concept Learning

Microdevice for continuous flow magnetic separation for bioengineering applications

Transformation Inside a Null-Space Region and a Dc Magnetic Funnel for Achieving an Enhanced Magnetic Flux With a Large Gradient

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