An Oligomeric Diet Limits the Response to Injury in Traumatic Brain-Injured Rats

Moinard, Christophe; Delpierre, Eric; Loi, Camilla; Neveux, N.; Butel, Marie‐José; Cynober, Luc; Charrueau, Christine

doi:10.1089/neu.2012.2707

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…They started the nutrition 4 h after TBI with a low flow, to reach the maximum flow at D1. In addition, ∆N or 3-Mhis/creatinine ratio were not measured in some key papers [29]. Our data, however, highlight differences in profiles between the three models: the LPS and TBI models presented a more marked myofibrillar catabolism on D2 than did TBI-Ec.…”

Section: Effect Of Type Of Injury On Protein Metabolismmentioning

confidence: 55%

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Citrulline and muscle protein homeostasis in three different models of hypercatabolism

Kuçi¹,

Verlaan²,

Vicente³

et al. 2020

Clinical Nutrition

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Section: Effect Of Type Of Injury On Protein Metabolismmentioning

confidence: 55%

“…EN in rodents via gastrostomy is a well-validated method in our laboratory [29]. Animals that were to be enterally fed (see below) were fasted from 5 pm on D−8 and underwent gastrostomy on D−7 (Figure 1).…”

Section: • Enteral Nutrition (En)mentioning

confidence: 99%

Citrulline and muscle protein homeostasis in three different models of hypercatabolism

Kuçi¹,

Verlaan²,

Vicente³

et al. 2020

Clinical Nutrition

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“…For instance, in an animal TBI study, oligonucleotide-based therapies produced some promising results. Oligomeric diets demonstrated potential benefits in rat models of TBI, preventing TBI-induced weight loss and thymus atrophy and, by extension, averting immune dysfunction [52].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Serum Concentrations of Pro- and Anti-Inflammatory Cytokines and Nutritional Status in Patients with Traumatic Head Injury in the Intensive Care Unit

et al. 2019

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Background and objective: The aim of the present study was to examine the relationship between serum levels of pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) and anti-inflammatory cytokines (IL-10) measured once at the baseline with changes in nutritional status of patients with traumatic head injury (THI) assessed at three consecutive times (24 h after admission, day 6 and day 13) during hospital stay in the intensive care unit (ICU). Materials and Methods: Sixty-four patients with THI were recruited for the current study (over 10 months). The nutritional status of the patients was determined within 24 h after admission and on days 6 and 13, using actual body weight, body composition analysis, and anthropometric measurements. The APACHE II score and SOFA score were also assessed within 24 h of admission and on days 6 and 13 of patients staying in the ICU. Circulatory serum levels of cytokines (IL-6, IL-1β, TNF-α, and IL-10) were assessed once within 24 h of admission. Results: The current study found a significant reduction in BMI, FBM, LBM, MAUAC, and APM, of THI patients with high serum levels the cytokines, over the course of time from the baseline to day 7 and to day 13 in patients staying in the ICU (p < 0.001). It was also found that patients with low levels of some studied cytokines had significant improvement in their nutritional status and clinical outcomes in term of MAUAC, APM, APACHE II score and SOFA score (p < 0.001 to p < 0.01). Conclusion: THI patients who had high serum levels of studied cytokines were more prone to develop a reduction of nutritional status in terms of BMI, FBM, LBM MAUAC and APM over the course of time from patient admission until day 13 of ICU admission.

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“…Moinard et al [63] evaluated the role of a 100% WHP semi-elemental formula compared with the standard polymeric formula among rats with traumatic brain injury. The authors reported an improvement in glutamine concentration among rats receiving a 100% WHP formula, suggesting that the use of a semi-elemental formula may limit response to injury after suffering a traumatic brain injury [63] .…”

Section: Peer-reviewmentioning

confidence: 99%

Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature

Alexander¹,

Bylsma²,

Elkayam³

et al. 2016

WJGPT

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AIM:To critically review and summarize the literature on nutritional and health outcomes of semi-elemental formulations on various nutritionally vulnerable patient populations who are unable to achieve adequate nutrition from standard oral diets. METHODS:We conducted a comprehensive literature search of Pubmed and Embase databases. We manually screened articles that examined nutritional and health outcomes (e.g. , growth, disease activity, gastrointestinal impairment, mortality, and economic impact) among various patient groups receiving semi-elemental diets. This review focused on full-text articles of randomized controlled clinical trials and other intervention studies, but pertinent abstracts and case studies were also included. Results pertaining primarily to tolerance, digestion, and absorption were summarized for each patient population in this systematic review.

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An Oligomeric Diet Limits the Response to Injury in Traumatic Brain-Injured Rats

Cited by 5 publications

References 24 publications

Citrulline and muscle protein homeostasis in three different models of hypercatabolism

Citrulline and muscle protein homeostasis in three different models of hypercatabolism

The Relationship between Serum Concentrations of Pro- and Anti-Inflammatory Cytokines and Nutritional Status in Patients with Traumatic Head Injury in the Intensive Care Unit

Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature

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