An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study

Abstract

Interest has arisen on the anti-inflammatory action of dietary components, including long-chain n-3 fatty acids (LCn3) and polyphenols (PP). The aim of this study was to evaluate the effects of diets rich in PP and oily fish (high-LCn3 diets) on markers of subclinical inflammation and growth factors in people at high cardiometabolic risk. Individuals with high waist circumference and one more component of metabolic syndrome were randomized to one of the following isoenergetic diets: low LCn3&PP, high LCn3, high PP, high LCn3&PP. Before and after 8 weeks, fasting and postprandial plasma concentrations of hs-CRP and fasting serum concentrations of IL-1β, IL-4, IL-6, IL-10, IL-17, INF-γ, TNF-α, FGF, VEGF, PDGF-ββ, G-CSF, and GM-CSF were determined. An oily fish diet reduced fasting plasma hs-CRP (1.28 ± 12.0, −12.5 ± 6.9, 22.5 ± 33.6, −12.2 ± 11.9; 8-week percent change, Mean ± SEM; low LCn3&PP, high LCn3, high PP, high LCn3&PP group, respectively), postprandial 6h-AUC hs-CRP (4.6 ± 16.3, −18.2 ± 7.2, 26.9 ± 35.1, −11.5 ± 11.8, 8-week percent change) and fasting IL-6 (20.8 ± 18.7, −2.44 ± 12.4, 28.1 ± 17.4, −9.6 ± 10.2), IL-17 (2.40 ± 4.9, −13.3 ± 4.9, 3.8 ± 4.43, −11.5 ± 4.7), and VEGF (−5.7 ± 5.8, −5.6 ± 7.5, 3.5 ± 5.8, −11.1 ± 5.5) (8-week percent change; p < 0.05 for LCn3 effect for all; no significant effect for PP; 2-factor ANOVA). An oily fish diet improved subclinical inflammation, while no significant effect was observed for dietary polyphenols.

Association of oily fish and nonoily fish intakes with all-cause mortality and cause-specific mortality: a large population-based prospective study

“…A previous study indicated that fish oil treatment could decrease the serum levels of the nitric oxide metabolites IL-1β, IL-6, and TNF-α [ 30 ]. An oily fish diet may improve subclinical inflammation [ 31 ]. The potential reason for observing a stronger protective effect in non-smokers is that these smokers were in a state of lower inflammatory stress at baseline.…”

Health benefits and health risks of contaminated fish consumption: Current research outputs, research approaches, and perspectives

“…Finally, there is evidence to suggest that regular fish consumption may have anti-inflammatory [ 36 ], analgesic (anti-nociceptive) [ 37 ] and immunoregulatory [ 2 ] properties. This is due to the presence of certain bioactive compounds found in fish, such as astaxanthin and omega-3 fatty acids, which can help reduce inflammation throughout the body.…”

Síndrome De Stevens-Johnson Ocasionada Pelo Uso De Fenitoína: Relato De Caso

“…As doenças cardiovasculares são patologias crônicas não transmissíveis e são responsáveis por grande número de mortes no mundo. Assim, nesse sentido, surgem estudos sobrea administração oral de ácidos graxos ômega-3 como estratégia profilática e terapêutica capaz de reduzir o risco cardiovascular (ROUSSEAU, 2021; NAS-CIMENTO e SCALABRINI, 2020); SANTOS et al, 2020;COSTABILE et al, 2021). pia de orientação à realidade (TOR) e orientação aos familiares e cuidadores.…”