An Ofloxacin-Induced Anaphylaxis through an IgG4-Mediated but Not IgE-Mediated Basophil Activation Mechanism

Kim, Ji Hye; Seo, Dae-Hong; Ban, Ga Young; Yang, Eun‐Mi; Shin, Yoo Seob; Ye, Young-Min; Park, Hae‐Sim

doi:10.4266/kjccm.2017.00108

Cited by 1 publication

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References 14 publications

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“…Patients with quinolone immediate allergic hypersensitivity display a significantly higher prevalence of QA sensitization than patients with quinolone immediate nonallergic hypersensitivity reactions and the general population. The key pathogenic mechanism behind ofloxacin hypersensitivity is an IgEmediated response to the hapten component of the drug [14,15].…”

Section: Case Reportmentioning

confidence: 99%

A Case Presentation on Ofloxacin Induced Dermal Hypersensitivity Reaction

Divya

Thankachan

2022

Int J Pharm Pharm Sci

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Ofloxacin is a second-generation fluoroquinolone and is highly effective against a wide range of bacterial infections. Fluoroquinolones are well-tolerated drugs with mild-to-moderate adverse effects such as gastrointestinal disturbances, skin reactions, and neurological reactions. These are widely used antimicrobials, which can cause cutaneous ADRs in about 1%–2% of patients. Hypersensitivity reactions due to ofloxacin are found rarely, ranging in frequency from 0.4% to 2%, respectively. This case report highlights one such event of cutaneous ADR by the use of ofloxacin injection causing Injection site reaction after a few minutes of Ofloxacin infusion. Based on history and clinical examination patient was diagnosed as ofloxacin induced hypersensitivity reaction and was successfully treated with antihistamines and corticosteroids. General management of ADR includes withdrawal/suspension, dose reduction of the suspected drug, and administration of supportive therapy. In this case, the suspected drugs were withdrawn and the patient was treated symptomatically. Pharmacovigilance should be a part of patient care to reduce the occurrence of adverse drug reactions and also encourage practitioners in reporting to gather more and more data regarding adverse drug reactions. Due to the rarity of Ofloxacin induced ADRs this article sheds light on one of such cases to help in pharmacovigilance

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Section: Case Reportmentioning

confidence: 99%