An Official American Thoracic Society Research Statement: Current Understanding and Future Research Needs in Tobacco Control and Treatment

Leone, Frank T.; Carlsen, Kai Håkon; Folan, Patricia; Latzka, Karen; Munzer, Alfred; Neptune, Enid; Pakhalé, Smita; Sachs, David P.L.; Samet, Jonathan M.; Upson, Dona; White, Alexander C.

doi:10.1164/rccm.201506-1081st

Cited by 19 publications

(10 citation statements)

References 191 publications

(198 reference statements)

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“…Similarly, ETS exposures may have differential impact based on source, timing, and exposure, including prenatally. 43 Our analysis supports developmental implications of smoke exposure in pregnancy and early childhood. Dose-dependent in utero smoke exposure has been associated with decreased lung function measures in healthy newborns, and infants with CF exposed to ETS have been reported to have more bronchial hyperreactivity.…”

Section: Impact Of Ses and Ets On Chest Examination Findingssupporting

confidence: 68%

Socioeconomic Status, Smoke Exposure, and Health Outcomes in Young Children With Cystic Fibrosis

et al. 2017

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Section: Impact Of Ses and Ets On Chest Examination Findingssupporting

confidence: 68%

Socioeconomic Status, Smoke Exposure, and Health Outcomes in Young Children With Cystic Fibrosis

et al. 2017

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“…2,4,6,7 Unfortunately, worldwide tobacco control is highly variable and highly dependent on a complex interaction between governmental regulation, taxation, public awareness, social patterns, the tobacco industry, and people who consume tobacco products. 8 In countries with stronger tobacco control laws, reductions in lung cancer incidence and mortality lag behind reductions in smoking prevalence by approximately 20 years. 2,4 However, tobacco consumption continues to rise in several developed countries, including the People's Republic of China, where the health burden caused by tobacco is also expected to continue to rise.…”

Section: Tobacco Control and Lung Cancer Preventionmentioning

confidence: 99%

Scientific Advances in Lung Cancer 2015

Tsao

Scagliotti

Bunn

et al. 2016

Journal of Thoracic Oncology

247

185

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Lung cancer continues to be a major global health problem; the disease is diagnosed in more than 1.6 million new patients each year. However, significant progress is underway in both the prevention and treatment of lung cancer. Lung cancer therapy has now emerged as a "role model" for precision cancer medicine, with several important therapeutic breakthroughs occurring during 2015. These advances have occurred primarily in the immunotherapy field and in treatments directed against tumors harboring specific oncogenic drivers. Our knowledge about molecular mechanisms for oncogene-driven tumors and about resistance to targeted therapies has increased quickly over the past year. As a result, several regulatory approvals of new agents that significantly improve survival and quality of life for patients with lung cancer who have advanced disease have occurred. The International Association for the Study of Lung Cancer has gathered experts in different areas of lung cancer research and management to summarize the most significant scientific advancements related to prevention and therapy of lung cancer during the past year.

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“…Exposure to second-hand tobacco smoke (SHS) is an established risk factor for non-malignant respiratory disease, especially among children, and also for cancer in adults [ 1 – 4 ]. Studies that have investigated respiratory effects among children exposed to SHS also have reported an increased risk of later developing chronic obstructive pulmonary disease in adulthood [ 2 , 5 ]. However, knowledge about the association between SHS exposure in households and non-malignant respiratory effects in adults is limited [ 6 – 10 ], relatively few studies have restricted their analyses to never-smokers [ 7 , 10 , 11 ], or stratified analyses by gender [ 6 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Exposure to second-hand tobacco smoke and respiratory symptoms in non-smoking adults: cross-sectional data from the general population of Telemark, Norway

et al. 2018

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BackgroundIn Norway, data on the association between second-hand tobacco smoke (SHS) exposure at home and respiratory symptoms in adults are limited.MethodsWe assessed the association between self-reported exposure to SHS and the prevalence of respiratory symptoms among never-smokers aged 16 to 50 years from the general population who were included in a cross-sectional population-based study in Telemark County, Norway. Logistic regression analysis was used to estimate the odds ratios of symptoms among 8850 never-smokers who provided an affirmative response to questions regarding SHS; 504 (5.7%) of these reported that they lived in a home with daily or occasional indoor smoking.ResultsProductive cough and nocturnal dyspnoea were statistically associated with daily SHS exposure (ORs 1.5 [95% CI 1.04–2.0] and 1.8 [1.2–2.7], respectively). In analyses stratified by gender, nocturnal dyspnoea was associated with SHS among women (OR 1.8 [1.1–3.1]), but not among men (OR 0.93 [0.49–1.8]). Symptoms were not associated with occasional SHS exposure in the entire group, but infrequent exposure among men only was associated with increased prevalence of chronic cough; (OR 1.6; [1.04–2.6]) and was negatively associated with wheeze; (OR 0.44 [0.21–0.92)].ConclusionsDaily SHS exposure in private homes was associated with productive cough and nocturnal dyspnoea. Our results suggest that preventive measures may be needed to reduce the respiratory effects of SHS at home.Trial registrationClinicalTrials.gov Identifier: NCT02073708 Registered February 27. 2014.

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An Official American Thoracic Society Research Statement: Current Understanding and Future Research Needs in Tobacco Control and Treatment

Abstract: In the coming era of tobacco research, pooled talent from multiple disciplines will be required to further illuminate the complex social, environmental and biological codeterminants of tobacco dependence.

Cited by 19 publications

References 191 publications

Socioeconomic Status, Smoke Exposure, and Health Outcomes in Young Children With Cystic Fibrosis

Socioeconomic Status, Smoke Exposure, and Health Outcomes in Young Children With Cystic Fibrosis

Scientific Advances in Lung Cancer 2015

Exposure to second-hand tobacco smoke and respiratory symptoms in non-smoking adults: cross-sectional data from the general population of Telemark, Norway

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