An Office-Based Prospective Study of Deafness in Mumps

Hashimoto, Hiromi; Fujioka, Masashi; Kinumaki, Hiroshi

doi:10.1097/inf.0b013e31818a8ca8

Cited by 68 publications

(40 citation statements)

References 6 publications

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“…This study confirmed that the majority of hearing loss due to mumps presented as unilateral profound sensorineural hearing loss, and was refractory to various treatments, such as steroids, vasodilators, vitamin B 12 and hyperbaric oxygen therapy. Our results concerning the hearing prognosis are consistent with those reported in the previous published literature [4][5][6]. Meanwhile, one patient with severe hearing loss showed improvement.…”

Section: Discussionsupporting

confidence: 83%

“…It has been estimated that the incidence of hearing loss due to mumps ranges from approximately 1 per 1000 to 1 per 20,000 mumps cases [6,11]. In the previous epidemiological study of mumps deafness in Japan, there was a definite peak in the age distribution at 5-9 years old [4].…”

Section: Discussionmentioning

confidence: 99%

“…Although steroids have been clinically administered in cases of mumps deafness according to the treatments for idiopathic sudden sensorineural hearing loss, the prognosis for patients with profound impairment is generally poor [4][5][6]. Meanwhile, spontaneous recovery in cases with mild hearing loss has been reported [7].…”

Section: Introductionmentioning

confidence: 99%

“…Hearing loss due to mumps is thought to be unilateral and profound with rapid onset [4][5][6]. Although steroids have been clinically administered in cases of mumps deafness according to the treatments for idiopathic sudden sensorineural hearing loss, the prognosis for patients with profound impairment is generally poor [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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The clinical features and prognosis of mumps-associated hearing loss: a retrospective, multi-institutional investigation in Japan

Morita

Fujiwara

Fukuda

et al. 2017

Acta Oto-Laryngologica

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Conclusions:The majority of hearing loss due to mumps presents as unilateral profound sensorineural hearing loss, which is refractory to treatment. In rare cases of bilateral total deafness, cochlear implants were beneficial for speech perception. Vaccination against mumps is recommended to prevent mumps-associated hearing loss. Objective: The objective of this study is to investigate the clinical characteristics of hearing loss due to mumps and to evaluate hearing outcomes. Subjects and methods: The clinical parameters were analyzed under a retrospective multi-institutional study design in patients diagnosed with hearing loss due to mumps at the Otolaryngology departments of 19 hospitals between 1987 and 2016. Results: Sixty-seven patients with hearing loss due to mumps were enrolled. The study population consisted of 35 males and 32 females, ranging in age from 1 to 54, with a median age of 9.5 years. Sixty-three patients presented with unilateral, and 4 with bilateral hearing loss. Profound hearing loss was observed in 65 ears. Only one ear with severe hearing loss showed complete recovery. Four patients with bilateral hearing loss received cochlear implant surgery. Most of the patients with hearing loss due to mumps had no history of vaccination. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The clinical features and prognosis of mumps-associated hearing loss: a retrospective, multi-institutional investigation in Japan

Morita

Fujiwara

Fukuda

et al. 2017

Acta Oto-Laryngologica

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“…In the study done by Hashimoto H, they reported that most of the mumps cases occured in school aged children of 5-14yrs age (60%) during 1985-1987 13 . Another study done by SR Palmer also confi rms that most of them occurred in preschool children 14 .…”

Section: Resultsmentioning

confidence: 99%

Study of Mumps in Children attending a Tertiary Care Centre

Keyal

Joshi

Bhatt

et al. 2012

J. Nepal Paedtr. Soc.

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Introduction: Mumps is a self-limiting viral infection of the salivary glands with systemic manifestations and complications. It primarily affects young children, with increased incidence in winter and spring. Mumps infection is endemic in developing countries because of poor vaccination coverage. This study is intended to highlight the increased number of mumps cases in children attending tertiary care center in Nepal and thus to emphasize the importance of mumps vaccination, so as to decrease the disease occurrence and disease burden by vaccinating all children. Materials and Methods: This was a prospective study done in Civil Service Hospital of Nepal over a period of 2 years from November 2009 to October 2011. All children less than 14years of age with symptoms of fever and parotid swelling were included in the study group. A detailed history pertaining to the disease was taken, that included; history of exposure and prior vaccination against mumps. Children were asked to follow up either after 5 days or in case of noticing any signs and symptoms of complication. Results: There were total 113 cases diagnosed clinically as mumps of which there were 71 males (62.83%) and 42 females (37.16%) with the peak incidence of disease in the month of March and September with 22 cases (19.46%) in each month. The increase incidence was seen in 4-6 years of age with 58 cases (51.32%). There were 70 patients (61.94%) that had history of exposure to mumps infection. All the patients in this study had either unilateral or bilateral parotitis. None of the children were vaccinated against mumps. And all the school going children had to be off school for a period of 3-5 days. Conclusion: There were large number of children with mumps and none of them were vaccinated. Child can be prevented from the infection by vaccination and thus avoiding possible sufferings and complications. Thus we recommend the use of mumps vaccination in Routine immunization programme. Key words: Mumps; Parotitis; School absenteeism; Nepal; Vaccine DOI: http://dx.doi.org/10.3126/jnps.v32i1.5499 J. Nepal Paediatr. Soc. Vol.32(1) 2012 53-56

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Molecular biology, pathogenesis and pathology of mumps virus

Rubin

Eckhaus

Rennick

et al. 2014

The Journal of Pathology

189

139

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Mumps is caused by the mumps virus (MuV), a member of the Paramyxoviridae family of enveloped, non-segmented, negative-sense RNA viruses. Mumps is characterized by painful inflammatory symptoms, such as parotitis and orchitis. The virus is highly neurotropic, with laboratory evidence of central nervous system (CNS) infection in approximately half of cases. Symptomatic CNS infection occurs less frequently; nonetheless, prior to the introduction of routine vaccination, MuV was a leading cause of aseptic meningitis and viral encephalitis in many developed countries. Despite being one of the oldest recognized diseases, with a worldwide distribution, surprisingly little attention has been given to its study. Cases of aseptic meningitis associated with some vaccine strains and a global resurgence of cases, including in highly vaccinated populations, has renewed interest in the virus, particularly in its pathogenesis and the need for development of clinically relevant models of disease. In this review we summarize the current state of knowledge on the virus, its pathogenesis and its clinical and pathological outcomes.

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An Office-Based Prospective Study of Deafness in Mumps

Abstract: The incidence of hearing loss in children due to mumps was 7/7400 (approximately 1/1000 cases), which is higher than previously suggested. Prevention of deafness is another important reason for assuring universal immunization against mumps.

Cited by 68 publications

References 6 publications

The clinical features and prognosis of mumps-associated hearing loss: a retrospective, multi-institutional investigation in Japan

The clinical features and prognosis of mumps-associated hearing loss: a retrospective, multi-institutional investigation in Japan

Study of Mumps in Children attending a Tertiary Care Centre

Molecular biology, pathogenesis and pathology of mumps virus

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