An off-on fluorescent probe for real-time sensing the fluctuations of intracellular pH values in biological processes

Zhang, Jie; Li, Jianguo; Chen, Bochao; Kan, Jianfei; Jiang, Tiantian; Zhang, Weifen; Yue, Jie-Yu; Zhou, Jin

doi:10.1016/j.dyepig.2019.107620

Cited by 20 publications

(12 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have seen that naphthalimide has been used to design pH probes (dual fluorophore based) in combination with other fluorophores. Naphthalimide fluorophore‐based ‘turn on’ type pH probe 51 is also developed [81a] . The probe showed fluorescence ‘turn on’ while moving from the acidic to basic pH.…”

Section: Other Ph Probesmentioning

confidence: 99%

Recent Advances in Small Molecule‐Based Intracellular pH Probes

et al. 2021

View full text Add to dashboard Cite

Intracellular pH plays an important role in many biological and pathological processes. Small‐molecule based pH probes are found to be the most effective for pH sensing because of ease of preparation, high sensitivity, and quick response. They have many advantages such as small perturbation to the functions of the target, functional adaptability, cellular component‐specific localization, etc. The present review highlights the flurry of recent activity in the development of such probes. The probes are categorized based on the type of fluorophore used like quinoline, coumarin, BODIPY, rhodamine, indolium, naphthalimide, etc., and their analytical performance is discussed.

show abstract

Section: Other Ph Probesmentioning

confidence: 99%

Recent Advances in Small Molecule‐Based Intracellular pH Probes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Additionally, the pathology of many diseases is also closely related to the changes in pH inside the body. Abnormal pH values in cells can cause cellular disorder [21]. For example, the pH value of cancer cells is lower than that of normal cells [22,23].…”

Section: Introductionmentioning

confidence: 99%

Water-stable perovskite-on-polymer fluorescent microspheres for simultaneous monitoring of pH, urea, and urease

Chen

Liu

et al. 2021

Anal Bioanal Chem

View full text Add to dashboard Cite

Perovskite materials have attracted attention due to their excellent optical and electrical properties, however, their unsatisfactory stability limits their application in biochemical detection. In this paper, CsPbBr3 perovskite quantum dots were successfully encapsulated in poly (styrene/acrylamide) microspheres, using a swelling-shrinking method. The manufactured perovskite microspheres (PDPS composites) not only maintained strong photoluminescence (PL) stability but also demonstrated great water solubility. Additionally, a real-time pH monitoring platform was constructed based on the prepared PDPS composites and dopamine, and the system showed a good linear relationship in a pH range of 4-12. Furthermore, urea could be hydrolyzed to produce hydroxyl groups, thereby increasing the pH of the solution. Therefore, this system was then extended for urea and urease detection. As a result, the detection limits of urea and urease were recorded as 1.67 μM and 2.1 mU/mL, respectively. This development provides an interesting demonstration of the expanding list of applications of perovskite materials.

show abstract

“…[9,10]. Bioluminescent molecule (luciferin) and different synthetic fluorophores bearing this substituent are well known [11][12][13][14][15][16][17][18][19]. Introduction of hydroxy groups usually causes the changes in electronic properties owing to its strong electron-donating nature and increases the intramolecular charge transfer (ICT) effect.…”

Section: Introductionmentioning

confidence: 99%

Sensitivity of the phenoxy derivatives of 2,4-dihydro-5H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ones to acidic and basic stimuli

Eltyshev

Belskaya

2021

Chim.Tech.Acta

View full text Add to dashboard Cite

Herein we report the research on the sensitivity of six hydroxy derivatives of dihydrotriazolopyrimidines (HO-DTP) to acids and bases. The UV/Vis and fluorescence spectra of these compounds were investigated with the addition of the acids and bases. Spectral data revealed the strong red shifts for emission and absorption maxima in the presence of KOH and NaOH. Moreover, two DTPs demonstrated strengthening of the emission intensity. The obtained results and data published in our previous paper demonstrated the strong and selective sensory response of DTPs to the acids and bases and elucidated relationships between the structure and sensitivity to the environment. This finding allowed us to manage these properties by introducing the combination of substituents and functionalities into the heterocyclic core. Thus, investigations demonstrated the potential of the application of DTPs as chemo- and fluorosensors for selective detection of acids and bases.

show abstract

An off-on fluorescent probe for real-time sensing the fluctuations of intracellular pH values in biological processes

Cited by 20 publications

References 38 publications

Recent Advances in Small Molecule‐Based Intracellular pH Probes

Recent Advances in Small Molecule‐Based Intracellular pH Probes

Water-stable perovskite-on-polymer fluorescent microspheres for simultaneous monitoring of pH, urea, and urease

Sensitivity of the phenoxy derivatives of 2,4-dihydro-5H-[1,2,3]triazolo[4,5-d]pyrimidin-5-ones to acidic and basic stimuli

Contact Info

Product

Resources

About