An odyssey through salpingitis isthmica nodosa

Bolaji, Ibrahim; Oktaba, Monika; Mohee, Kevin; Sze, Ka Yan Shirley

doi:10.1016/j.ejogrb.2014.11.014

Cited by 11 publications

(4 citation statements)

References 28 publications

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“…The diagnosis of endometritis in the bovine is done either by ultrasonography or microscopic analyses of (a) cellular material obtained with the cytobrush 39–42 , (b) fluid obtained by uterine flushing 43,44 or (c) endometrial smears determining polymorphonuclear neutrophils (PMNs), lymphocytes and macrophages 38,39 . However, specific diagnostic tools for bovine salpingitis are lacking as the oviducts are well hidden in the abdomen and cannot be visualized by routine imaging technologies 45,46 .…”

Section: Introductionmentioning

confidence: 99%

“…Chronic salpingitis can be asymptomatic, however some acute symptoms include adnexal tenderness, lower abdominal pain and low back pain while some cases of salpingitis are misdiagonsed as acute appendicitis as symptoms are similar 57,58 . In general, laparoscopy is the gold standard to diagnose and confirm the presence of acute salpingitis 45,46 . Salpingitis often causes tubal occlusion and hydrosalpinx 20,21,59 which might result in ectopic pregnancy 60 .…”

Section: Introductionmentioning

confidence: 99%

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Salpingitis Impairs Bovine Tubal Function and Sperm-Oviduct Interaction

Owhor

Reese²,

Kölle

2019

Sci Rep

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Salpingitis is a common cause for subfertility and infertility both in humans and animals. However, the effects of salpingitis on tubal function and reproductive success are largely unknown. Therefore we set out to investigate the effects of inflammation on sperm and oocyte transport and gameto-maternal interaction in the oviduct using the bovine as a model. For this purpose, oviducts revealing mild (n = 45), moderate (n = 55) and severe (n = 45) inflammation were obtained from cows immediately after slaughter and investigated by live cell imaging, histochemistry and scanning electron microscopy. Our studies showed that endometritis was always correlated with salpingitis. Moderate and severe inflammation caused a significant increase in the thickness of tubal folds (p < 0.05). Severe inflammation was characterized by luminal accumulations of mucus and glycoproteins, increased apoptosis, loss of tight junctions and shedding of tubal epithelial cells. The mean ciliary beat frequency (CBF) in the ampulla was significantly reduced as compared to the controls (p < 0.05). The higher the grade of inflammation, the lower was the CBF (p < 0.001). In severe inflammation, spermatozoa were stuck in mucus resulting in decreased sperm motility. Our results imply that tubal inflammation impairs proper tubal function and leads to reduced sperm fertilizing capacity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Salpingitis Impairs Bovine Tubal Function and Sperm-Oviduct Interaction

Owhor

Reese²,

Kölle

2019

Sci Rep

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“…(27,33) In the present study, the tubercle (Figure 6) was seen almost half of the cases of biopsy-proven endometrial tuberculosis, and around one-third of patients had the isthmo-ampulary block, encysted fluid collection, and caseous material. Nodular growth in the isthmic section of the fallopian tube is called salpingitis isthmic nodosa (SIN) (34), which is often endoscopically seen as an isthmo-ampullary block or nodule. It is common in underdeveloped countries and is caused by TB, which invades the isthmic region of the fallopian tube directly between the lumen and the serosa, affecting the muscularis layer.…”

Section: Discussionmentioning

confidence: 99%

Hysteroscopic and Laparoscopic finding in Infertile Women with proven Endometrial Tuberculosis

Mondal

Jaiswal

Bhave

2023

Preprint

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Background: Currently, none of the diagnostic procedures for detecting female genital tuberculosis (FGTB) are 100 percent reliable, and the same is true for endoscopic results. There are several studies accessible on hysteroscopic and laparoscopic findings that are suggestive of TB. However, no study to our knowledge summarises the findings of laparoscopic and hysteroscopic examination in subfertile female patients with biopsy, culture, or other laboratory test-proven endometrial tuberculosis. Objective: Evaluation of hysteroscopic and laparoscopic findings in subfertile women suffering from proven endometrial tuberculosis. Materials and methods: 16,784 infertile women had a diagnostic hysterolaparoscopy between February 2014 and June 2021, among which 1084 patients were prescribed anti-tubercular medication based on the results of their findings; however, only 309 individuals had endometrial tuberculosis verified via positive on histopathology examination, AFB demonstration, Culture, and GeneXpert MTB/RIF. We retrospectively observed the diagnostic hysterolaparoscopy findings in those proven cases of subfertile women suffering from FGTB. Results: The major findings on hysteroscopy were periosteal fibrosis (209/309,67.63%), pale endometrium(179/309,57.92%), and micro polyp(138/309,44.66%). Other notable hysteroscopic findings were intrauterine adhesions (88/309,28.47%), endometrial tubercle (78/309,25.24%), endometrial polyp(54/309,14.88%), caseation(42/309,13.59%), focal hyperemia(29/309,9.38%) and diffuse hyperemia(18/309,5.82%). The most common finding on laparoscopy was abdominopelvic adhesions of various grades (297/309,96.11%). The major findings of laparoscopy were tubercle (155/309,50.16%), isthmo ampullary block (118/309,38.18%), tubal diverticula (116/309,37.54%), hydrosalpinx (97/309,31.39%) and TO mass (96/309,31.06%). 5.50% (17/300) had a normal appearance on hysteroscopy, and 1.29% (4/309) had a normal-looking pelvis on laparoscopy. Conclusions: In proven endometrial tuberculosis, significant hysteroscopic findings are periosteal fibrosis, pale endometrium, micro-polyp, and intrauterine adhesions, whereas major laparoscopic findings are various grades of abdominal pelvic adhesions, including perihepatic adhesions, miliary tubercle, isthmo ampullary block, tubal diverticula, caseous material, and hydrosalpinx. Tuberculosis should be considered if these signs are discovered during a diagnostic work-up in infertile people.

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“…Salpingitis isthmica nodosa [33][34][35] Salpingitis isthmica nodosa (SIN) is an acquired pathologic condition in which the fallopian tube epithelium invaginates into the muscularis layer of the fallopian tube. The incidence of SIN is estimated to be between 0.6 and 11%.…”

Section: Peritoneal and Adnexal Pathologymentioning

confidence: 99%

Don’t be STUMPed: description and management of uncommon pathologies encountered on specimens from benign gynecologic surgery

Chaves¹,

Curlin²,

Harvey³

et al. 2021

Current Opinion in Obstetrics &Amp; Gynecology

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Purpose of review In this review, we aim to describe uncommon pathologies that gynecologic surgeons may reasonably encounter on surgical specimens following benign gynecologic surgery. Recent findings Herein, we describe uncommon pathologic findings of the uterus (e.g. squamous morular metaplasia, fibroid variants, stromal tumor of uncertain malignant potential), peritoneum and adnexa (e.g. endosalpingiosis, serous tubal intraepithelial carcinoma), endometriosis (e.g. stromal endometriosis, atypical endometriosis), and findings of particular interest in postmenopausal women (e.g. ovarian cortical stromal hyperplasia, tubal metaplasia). The majority of pathologic findings presented in this article are inherently benign, although they can present diagnostic challenges. If properly classified, additional treatment and/or extended follow-up is often not required; exceptions are highlighted. Summary The gynecologic surgeon may encounter uncommon pathologies during a career. Inherent diagnostic difficulties, as well as nonstandardized or outdated terminology, can introduce further uncertainty. Whenever such a situation arises, the surgeon and pathologist should discuss the diagnosis to ensure appropriate treatment options.

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An odyssey through salpingitis isthmica nodosa

Cited by 11 publications

References 28 publications

Salpingitis Impairs Bovine Tubal Function and Sperm-Oviduct Interaction

Salpingitis Impairs Bovine Tubal Function and Sperm-Oviduct Interaction

Hysteroscopic and Laparoscopic finding in Infertile Women with proven Endometrial Tuberculosis

Don’t be STUMPed: description and management of uncommon pathologies encountered on specimens from benign gynecologic surgery

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