An observer-blinded study of 1% permethrin creme rinse with and without adjunctive combing in patients with head lice

Meinking, Terri L.; Clineschmidt, Coleen M.; Chen, Cong; Kolber, Michael A.; Tipping, Robert; Furtek, Christine; Villar, María Elena; Guzzo, Cynthia

doi:10.1067/mpd.2002.129031

Cited by 61 publications

(50 citation statements)

References 19 publications

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“…The posology and formulation excipients of phenothrin liquid, however, probably contribute towards activity to overcome low levels of resistance 12. Overall, the efficacy for both products was comparable to that found for malathion lotions applied by parents in North Wales in 1999 and the investigator led study of permethrin in the United States, although the latter, as an efficacy study may not represent consumer use 3 10…”

Section: Discussionmentioning

confidence: 75%

“…We assumed that success rates in the two groups would be 77.5%, based on current best evidence,3 10 but the design was sufficiently robust that if the true success rates proved lower, the power would be reduced but still remain high—for example, over 80% power for 70% true success rates. For 90% power the sample size required for each group was determined as 114; the sample size allowed for protocol violations.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial

Burgess¹,

Brown²,

2005

BMJ

127

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Objective To evaluate the efficacy and safety of 4% dimeticone lotion for treatment of head louse infestation. Design Randomised controlled equivalence trial. Setting Community, with home visits. Participants 214 young people aged 4 to 18 years and 39 adults with active head louse infestation. Interventions Two applications seven days apart of either 4.0% dimeticone lotion, applied for eight hours or overnight, or 0.5% phenothrin liquid, applied for 12 hours or overnight. Outcome measures Cure of infestation (no evidence of head lice after second treatment) or reinfestation after cure. Results Cure or reinfestation after cure occurred in 89 of 127 (70%) participants treated with dimeticone and 94 of 125 (75%) treated with phenothrin (difference − 5%, 95% confidence interval − 16% to 6%). Per protocol analysis showed that 84 of 121 (69%) participants were cured with dimeticone and 90 of 116 (78%) were cured with phenothrin. Irritant reactions occurred significantly less with dimeticone (3/127, 2%) than with phenothrin (11/125, 9%; difference − 6%, − 12% to − 1%). Per protocol this was 3 of 121 (3%) participants treated with dimeticone and 10 of 116 (9%) treated with phenothrin (difference − 6%, − 12% to − 0.3%). Conclusion Dimeticone lotion cures head louse infestation. Dimeticone seems less irritant than existing treatments and has a physical action on lice that should not be affected by resistance to neurotoxic insecticides.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial

Burgess¹,

Brown²,

2005

BMJ

127

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“…Previous studies found that adding the use of a special lice comb to treatment with pediculicides did not change the treatment success rates. [29] Thus, the current model assumes that those who use pediculicides do not use a lice comb as well.…”

Section: Technical Notesmentioning

confidence: 99%

Head Lice Treatments and School Policies in the US in an Era of Emerging Resistance

Gur

Schneeweiss

2009

PharmacoEconomics

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Our study suggests that permethrin 1% was the most cost-effective treatment for those with a willingness to pay of <$US162 per cure. Sensitivity of lice to permethrin and the specific school head lice policy had major effects on the model. Thus, informing communities in a given geographical area about the degree of head lice resistance and sensitivity is necessary in order for the public to make a rational decision regarding treatment. Schools' head lice policies have a major effect on the cost of head lice treatments.

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“…7,8 One study suggested that conventional nit combing did little to improve on the efficacy of 1% permethrin crème rinse. 9 Application of diluted vinegar or commercial preparations of 8% formic acid improves compliance by making combing easier, 10 but vinegar, formic acid, and an enzymatic nit remover have been shown to have little effect on the nit cement in vitro. 11 Methods to asphyxiate lice are now being investigated.…”

mentioning

confidence: 99%

Nit picking

Elston

2005

Journal of the American Academy of Dermatology

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An observer-blinded study of 1% permethrin creme rinse with and without adjunctive combing in patients with head lice

Cited by 61 publications

References 19 publications

Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial

Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial

Head Lice Treatments and School Policies in the US in an Era of Emerging Resistance

Nit picking

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