An Observational Study of Dermatological Manifestations in Patients of Chronic Renal Failure Undergoing Hemodialysis

Abstract

Background: Chronic Renal Failure (CRF) patients develop myriad of cutaneous findings. Novel cutaneous changes are being described since the introduction of hemodialysis, which prolongs the life expectancy, and thus more time for the skin changes to develop. Aims & Objectives: We aimed to evaluate the prevalence of dermatologic manifestations among the patients suffering from Chronic Renal Failure (CRF) who are on hemodialysis. Methods: 93 patients with CRF receiving hemodialysis were evaluated for skin, hair and nail changes. Results: All the enrolled patients experienced some skin problem. The most prevalent cutaneous manifestation was xerosis (54.8%), followed by pallor (21.5%), pruritus (19.35%) and dyspigmentation (18.3%). Other dermatologic manifestations included Kyrle's disease (5.4%); fungal (5.4%), bacterial (6.5%) and viral (3.2%) infections and purpura (9.7%). Recorded nail changes were half and half nail (21%), koilonychia (39.78%), onychomycosis (1.08%), onychorrhexis (6.45%), splinter hemorrhages (1.08%), and Beau's lines (2%). Hair changes included sparse hair (18.28%), and brittle and lustreless hair (11.83%). Oral cavity manifestations were enlarged tongue with teeth indentations (23.65%). Conclusions: CRF is associated with multiple skin, hair and nail manifestations caused either by the CRF or by its therapy. The commonest cutaneous changes were xerosis and pruritus.

Uremic xerosis among patients on maintenance hemodialysis: Prevalence and correlation with clinical and laboratory markers

“…In the current study, the observed prevalence of xerosis at 60.4% is consistent with the findings of studies conducted by Szepietowski et al, Balaskas et al, and Young et al [15][16][17][18]. However, it is lower than the prevalence reported in other investiga-tions [19][20][21][22][23][24][25][26][27] and higher than that reported in additional studies [28][29][30][31][32][33][34][35]. The lower prevalence of xerosis in our study, compared to many others, could be attributed to the reduced likelihood of xerosis during the summer, which corresponds to the period of our data Український журнал нефрології та діалізу №1 (81) 2024…”

“Impact of Hemodialysis Frequency and Duration on Changes in Haematological Markers and Electrolytes in Patients with End-Stage Renal Disease: A Prospective, Multi-Center Study”

“…Hemodialysis was associated with a suboptimal response to erythropoietin therapy in ESRD patients, and all haematological parameters differed between the control group, CKD stages, and age groups (2,(20)(21)(22). It may cause bleeding and coagulation abnormalities due to thrombocytopenia (23)(24)(25)(26). One study found that metabolic acidosis in well-dialyzed renal failure patients can be completely corrected (27).…”