An Observational Study of 11 French Liver Transplant Recipients Infected with Human Immunodeficiency Virus Type 1

Bouscarat, F.; Samuel, Didier; Simon, François; Debat, Pierre; Bismuth, H; Saimot, A. G.

doi:10.1093/clinids/19.5.854

Cited by 73 publications

(35 citation statements)

References 27 publications

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“…Transplantation outcomes in the pre-HAART era were generally poor (5)(6)(7)(8)(9). More contemporary retrospective analyses, case reports and small prospective studies suggest that patient and graft survival in selected HIV-infected patients may be similar to those seen in HIV-uninfected patients (10)(11)(12)(13)(14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

HIV-Infected Liver and Kidney Transplant Recipients: 1- and 3-Year Outcomes

Roland

Barin

Carlson

et al. 2008

American Journal of Transplantation

223

199

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Improvements in human immunodeficiency virus (HIV)-associated mortality make it difficult to deny transplantation based upon futility. Outcomes in the current management era are unknown. This is a prospective series of liver or kidney transplant recipients with stable HIV disease. Eleven liver and 18 kidney transplant recipients were followed for a median of 3.4 years (IQR [interquartile range] 2.9-4.9). One-and 3-year liver recipients' survival was 91% and 64%, respectively; kidney recipients' survival was 94%. One-and 3-year liver graft survival was 82% and 64%, respectively; kidney graft survival was 83%. Kidney patient and graft survival were similar to the general transplant population, while liver survival was similar to the older population, based on 1999-2004 transplants in the national database. CD4+ T-cell counts and HIV RNA levels were stable; and there were two opportunistic infections (OI). The 1-and 3-year cumulative incidence (95% confidence intervals [CI]) of rejection episodes for kidney recipients was 52% (28-75%) and 70% (48-92%), respectively. Two-thirds of hepatitis C virus (HCV)-infected patients, but no patient with hepatitis B virus (HBV) infection, recurred. Good transplant and HIV-related outcomes among kidney transplant recipients, and reasonable outcomes among liver recipients suggest that transplantation is an option for selected HIV-infected patients cared for at centers with adequate expertise.

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Section: Introductionmentioning

confidence: 99%

HIV-Infected Liver and Kidney Transplant Recipients: 1- and 3-Year Outcomes

Roland

Barin

Carlson

et al. 2008

American Journal of Transplantation

223

199

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“…29,30 It is important to recognize that not all patients with HIV and liver failure may be acceptable candidates for OLT. Patients with profound immunosuppression attributable to advanced AIDS or with a detectable viral load caused by HAART therapy from multiple drug resistance may not be good candidates for transplantation at this time.…”

Section: Discussionmentioning

confidence: 99%

Orthotopic liver transplantation in patients with human immunodeficiency virus and end-stage liver disease

Neff

Bonham

Tzakis

et al. 2003

Liver Transplantation

152

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“…Recipients had a shorter AIDS-free time compared with nontransplanted HIV+ patients (5, 6) and survival was poor compared with the general kidney or liver recipient population (7). Mortality was mainly related to AIDS, with Pneumocystis carinii pneumonia, Toxoplasma gondii, tuberculosis or CMV infections as major causes (5,8,9). Accordingly dialysis was considered to be the best available treatment for end-stage kidney disease in HIV+ patients.…”

Section: Discussionmentioning

confidence: 99%