An Observational Retrospective Real-World Study to Evaluate the Effect of Teneligliptin on Parameters of Renal Function, Glycemic Control, and Safety in Indian T2DM Patients with Chronic Kidney Disease (TOP RENAL)

Abstract

Background: Teneligliptin has shown better efficacy, tolerability and reduced associated complications in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). The aim of this study was to evaluate the effect of Teneligliptin on renal function and glycemic control in Indian T2DM patients with CKD in a real-world setting.Methodology: This was a retrospective, observational study that included 377 patients from 4 study sites across India. Details from prescriptions and laboratory investigations of individual patient were recorded. Primary and secondary outcomes measured were changes in the renal parameters, [eGFR, serum creatinine, and blood urea nitrogen] and glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and body weight at 3 months and 6 months (±2week) as compared to baseline.