An obligate microsporidian parasite modulates defense against opportunistic bacterial infection in the yellow fever mosquito , Aedes aegypti

Abstract

The microsporidium Edhazardia aedis is a parasite of the yellow fever mosquito, Aedes aegypti . This mosquito transmits multiple viruses to humans in the United States and around the world, including dengue, yellow fever, and Zika viruses. Hundreds of millions of people worldwide will become infected with one of these viruses each year. E. aedis infection significantly reduces the lifespan of Ae. aegypti and is therefore a promising novel biocontrol agent. Here, we show that when the mosquito is infected with this parasite, it is also significantly more susceptible to infection by an opportunistic bacterial pathogen, Serratia marcescens . This novel discovery suggests the mosquito’s ability to control infection by other microbes is impacted by the presence of the parasite.