An object location memory paradigm for older adults with and without mild cognitive impairment

Külzow, Nadine; Kerti, Lucia; Witte, Veronica; Kopp, Ute A.; Breitenstein, Caterina; Flöel, Agnes

doi:10.1016/j.jneumeth.2014.08.020

Cited by 14 publications

(14 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subjects were presented with a street map on which buildings were shown at different correct and incorrect positions. In this “statistical” learning paradigm (“LOCATO,” see also Kulzow et al, 2014 ), the “correct” position of a building occurred more frequently (10 times more often than any of the incorrect positions, which were shown only once) over the course of five training blocks. Outcome measures were learning success at the end of each session (after atDCS and sham) as well as immediate and delayed free recall one week later.…”

Section: Review Of Recent Tdcs Studies On Cognitive Decline In Older mentioning

confidence: 99%

Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS

Prehn

Flöel

2015

Front. Cell. Neurosci.

Self Cite

View full text Add to dashboard Cite

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that is increasingly used in research and clinical settings to enhance the effects of cognitive training. In our present review, we will first summarize studies using tDCS alone and in combination with cognitive training in older adults and patients with Alzheimer’s dementia (AD). We will also review one study (Meinzer et al., 2014c) that showed an improvement in cognitive performance during anodal tDCS over the left inferior frontal cortex in patients with mild cognitive impairment (MCI) which is regarded as a prodromal stage of AD. Although promising short-term results have been reported, evidence from randomized controlled trials (RCTs) with sufficient sample sizes is scarce. In addition, stimulation protocols (in terms of intensity, duration, and repetition of stimulation) that lead to sustained improvements in outcome measures relevant for daily life still remain to be established. Following, we will discuss modulating factors such as technical parameters as well as the question whether there are specific cognitive functions (e.g., learning, memory consolidation, executive control) which are more amenable to tDCS enhancement than others. Finally, we will highlight future directions and limitations in this field and emphasize the need to conduct RCTs to establish efficacy of interventions for activities of daily life for a given patient population.

show abstract

Section: Review Of Recent Tdcs Studies On Cognitive Decline In Older mentioning

confidence: 99%

Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS

Prehn

Flöel

2015

Front. Cell. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…For instance, patients were asked to pick out the items they have seen before and relocated them to previous positions (Kessels et al, 2000); the patients relocated the same objects to the positions previously presented (positions-only condition), different objects to the position marked by dots (object-to-position-assignment condition), different objects to the position without marks (combined condition) (Postma and De Haan, 1996; Kessels et al, 2002, 2010; van Asselen et al, 2008; Mazurek et al, 2015). Some paradigms also use pictures of real-life objects (e.g., buildings) on a map to recognize objects-location pairings (Kulzow et al, 2014; Edler et al, 2015). The 4 Mountains Test (4MT) is another brief behavioral test of spatial memory, and performance on it has been found to diagnose AD with high sensitivity and specificity (Hartley et al, 2007; Bird et al, 2010; Moodley et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Changes of EEG Spectra and Functional Connectivity during an Object-Location Memory Task in Alzheimer’s Disease

Han

Wang

Jia

et al. 2017

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Object-location memory is particularly fragile and specifically impaired in Alzheimer’s disease (AD) patients. Electroencephalogram (EEG) was utilized to objectively measure memory impairment for memory formation correlates of EEG oscillatory activities. We aimed to construct an object-location memory paradigm and explore EEG signs of it. Two groups of 20 probable mild AD patients and 19 healthy older adults were included in a cross-sectional analysis. All subjects took an object-location memory task. EEG recordings performed during object-location memory tasks were compared between the two groups in the two EEG parameters (spectral parameters and phase synchronization). The memory performance of AD patients was worse than that of healthy elderly adults The power of object-location memory of the AD group was significantly higher than the NC group (healthy elderly adults) in the alpha band in the encoding session, and alpha and theta bands in the retrieval session. The channels-pairs the phase lag index value of object-location memory in the AD group was clearly higher than the NC group in the delta, theta, and alpha bands in encoding sessions and delta and theta bands in retrieval sessions. The results provide support for the hypothesis that the AD patients may use compensation mechanisms to remember the items and episode.

show abstract

“…Visuospatial memory training was administered using the OLM paradigm [25,74], which was adopted for use in a 3-day OLM training (LOCATO-30) and is described in detail elsewhere [21]. In brief, subjects had to learn 30 object-location pairings on a two-dimensional street map over the course of five learning blocks at each day, followed by a recall task (see also Fig.…”

Section: Training Taskmentioning

confidence: 99%

Impact of 3-Day Combined Anodal Transcranial Direct Current Stimulation-Visuospatial Training on Object-Location Memory in Healthy Older Adults and Patients with Mild Cognitive Impairment

Sousa

Grittner

Rujescu

et al. 2020

JAD

Self Cite

View full text Add to dashboard Cite

Background: Associative object-location memory (OLM) is known to decline even in normal aging, and this process is accelerated in patients with mild cognitive impairment (MCI). Given the lack of curative treatment for Alzheimer's disease, activating cognitive resources during its preclinical phase might prevent progression to dementia. Objective: To evaluate the effects of anodal transcranial direct current stimulation (atDCS) combined with an associative episodic memory training on OLM in MCI patients and in healthy elderly (HE). Methods: In a single-blind cross-over design, 16 MCI patients and 32 HE underwent a 3-day visuospatial OLM training paired with either 20 min or 30 s (sham) atDCS (1 mA, right temporoparietal cortex). Effects on immediate (training success) and long-term memory (1-month) were investigated by conducting Mixed Model analyses. In addition, the impact of combined intervention on within-session (online) and on between-session (offline) performance were explored.

show abstract

An object location memory paradigm for older adults with and without mild cognitive impairment

Cited by 14 publications

References 49 publications

Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS

Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS

Changes of EEG Spectra and Functional Connectivity during an Object-Location Memory Task in Alzheimer’s Disease

Impact of 3-Day Combined Anodal Transcranial Direct Current Stimulation-Visuospatial Training on Object-Location Memory in Healthy Older Adults and Patients with Mild Cognitive Impairment

Contact Info

Product

Resources

About