Non-communicable diseases (NCDs) are a global epidemic. With the start of a new decade, new strategies and health goals are expected to be formulated. The aim was to investigate a highly prevalent NCD European state to assess the age of onset for most NCDs. Such evidence can aid in the development of new preventive strategies. Methods: A national health examination survey was conducted to explore the adult population (18-70 years) of Malta for common NCDs. Both self-reported and examination data were used to diagnose type 2 diabetes, dyslipidaemia, hypertension, overweight and obesity. The study population was stratified by ten years agegroups and sex for both descriptive and analytic analyses. Association studies were conducted to identify links between type 2 diabetes, dyslipidaemia, hypertension, overweight and obese status and different age groups, while adjusting for confounders. Results: The men were significantly more metabolically unhealthy that the women across all age groups. However, a higher newly diagnosed diabetes prevalence across all age groups was established for women. Dyslipidemia, diabetes and hypertension were observed to be present from the 30-39 year age group. On modelling, this age group was associated with these NCDs even after adjusting for confounders. Conclusion: The fourth decade of life appears to be the starting point of metabolic dysregulation, contributing to long-term health and economic burdens. Furthermore, considering this is a childbearing age group, metabolic impact can be transmitted on to their offspring. Preventive action including dysglycaemia and dyslipidaemia screening should be considered from a young age.