An O-acetyl-glucomannan from the rhizomes of Curculigo orchioides: Structural characterization and anti-osteoporosis activity in vitro

Wang, Xueqian; Zhang, Mengliu; Zhang, Dawei; Wang, Shumei; Yan, Chunyan

doi:10.1016/j.carbpol.2017.06.051

Cited by 42 publications

(17 citation statements)

References 33 publications

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“…Further in vitro and rat calvarial studies have shown that compounds isolated from CO appear to have antiosteoporotic properties, including the promotion of osteoblast proliferation and differentiation, increased bone-forming activity, and the inhibition of osteoclastic bone resorption. The bioactive compounds isolated from MO include novel homogeneous polysaccharides, COP90-1 and COP70-3, and phenolic glycosides (Jiao et al, 2009; Wang et al, 2013b; Wang et al, 2017c; Wang et al, 2019b).…”

Section: Natural Chinese Medicinesmentioning

confidence: 99%

Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis

Wang

et al. 2019

Front. Pharmacol.

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Osteoporosis is a bone disease characterized by increasing osseous fragility and fracture due to the reduced bone mass and microstructural degradation. Primary pharmacological strategies for the treatment of osteoporosis, hormone replacement treatment (HRT), and alendronate therapies may produce adverse side-effects and may not be recommended for long-term usage. Some classic and bone-specific natural Chinese medicine are very popularly used to treat osteoporosis and bone fracture effectively in clinical with their potential value in bone growth and development, but with few adverse side-effects. Current evidence suggests that the treatments appear to improve bone metabolism and attenuate the osteoporotic imbalance between bone formation and bone resorption at a cellular level by promoting osteoblast activity and inhibiting the effects of osteoclasts. The valuable therapies might, therefore, provide an effective and safer alternative to primary pharmacological strategies. Therefore, the purpose of this article is to comprehensively review these classic and bone-specific drugs in natural Chinese medicines for the treatment of osteoporosis that had been deeply and definitely studied and reported with both bone formation and antiresorption effects, including Gynochthodes officinalis (F.C.How) Razafim. & B.Bremer (syn. Morinda officinalis F.C.How), Curculigo orchioides Gaertn., Psoralea corylifolia (L.) Medik Eucommia ulmoides Oliv., Dipsacus inermis Wall. (syn. Dipsacus asperoides C.Y.Cheng & T.M.Ai), Cibotium barometz (L.) J. Sm., Velvet Antler, Cistanche deserticola Ma, Cuscuta chinensis Lam., Cnidium monnieri (L.) Cusson, Epimedium brevicornum Maxim, Pueraria montana (Lour.) Merr. and Salvia miltiorrhiza Bunge., thus providing evidence for the potential use of alternative Chinese medicine therapies to effectively treat osteoporosis.

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Section: Natural Chinese Medicinesmentioning

confidence: 99%

Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis

Wang

et al. 2019

Front. Pharmacol.

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“…It has been well‐established that autophagy plays an imperative role in the promotion of metabolic disorders such as diabetes, so we got interested in scrutinize the expression and modulation of autophagy signaling factors in STZ‐treated Rin‐5F cells exposed upon RCO. Antimicrobial, hypolipidemic, anti‐osteoporosis, immunomodulating, antioxidant, and anticancer activities as well as, modulation of several diseases through alteration of gut microbiota have been widely attributed to polysaccharides and oligosaccharides extracted from several sources from bacteria, fungal, and herbs (Lim, Yu, Kim, & Chung, 2016; Neyrinck et al., 2012; Ru et al., 2019; Wang, Zhang, Zhang, Wang, & Yan, 2017; Wang et al., 2019; Yang, Hsieh, Wen, Chiu, & Lin, 2017; Yu et al., 2013; Zheng et al., 2018; Zhu, Xue, & Zhang, 2016). There is increasing evidence that isolated polysaccharides have also been involved in the treatment of diabetes (Wang, Wang, et al, 2017; Wang, Wang, et al, 2017; Zhang, Huang, Hong, & Chen, 2019; Zhang et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of the isolated oligosaccharide from Rosa canina in STZ‐treated cells through modulation of the autophagy pathway

et al. 2020

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Diabetes mellitus (DM) is a metabolic and endocrine disorder that affects millions of people worldwide (Cho et al., 2018). DM is characterized by insulin resistance or progressive pancreatic β-cells devastation accompanied by a disturbance in the metabolism of carbohydrates, lipids, and proteins resulted in a multitude of microand macrovascular complications (Joshi et al., 2019; Luo et al., 2018). The conventional therapeutic options for treatment of DM exhibit insufficient efficacy and can result in several adverse effects including weight gain, hypoglycemia, as well as liver and kidney toxicity. Therefore, discovering new hypoglycemic agents with few side effects and desired potency is necessary to counteract insulin re

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“…SEM and Congo red analysis showed that COP90-1 was homogeneous with an inerratic ellipsoid shape instead of triple-helix structure. In vitro, COP90-1 effectively promoted the proliferation and differentiation of primary osteoblasts [ 33 ]. Two years later, Wang et al (2019) isolated and purified a novel homogeneous heteropolysaccharide COP70-3 ( 2 ) with a main backbone chain of (1→5)-linked α- l -Araf, (1,3→5)-linked α- l -Araf, (1→6)-linked β- d -Galp, (1→4)-linked β- d -Manp, (1,2→5)-linked α- l -Araf, (1→3)-linked β- l -Rhap, (1,3→6)-linked β- d -Manp, (1→3)-linked α- d -GalpA, (1,3→6)-linked β- d -Galp and (1→6)-linked α- d -Glcp residues.…”

Section: Phytochemistrymentioning

confidence: 99%

“…Beside the curculigoside ( 32 ), other compounds with anti-osteoporosis obtained from the plants of genus Curculigo activity were also documented. From the rhizomes of C. orchioides, Wang et al (2017, 2019) isolated two polysaccharides as COP90-1 ( 1 ) and COP70-3 ( 2 ), and both 1 and 2 displayed anti-osteoporosis activities in vitro [ 33 , 34 ]. Wang et al (2013; 2014; 2018) reported that nine chlorophenolic glucosides, curculigine E-G, I, and K–O ( 8 – 10 , 12 and 14 – 18 ), displayed anti-osteoporosis by increasing the proliferation rate by 10.1%–15.9% in MC3T3-E1 cells [ 44 , 45 , 46 ].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

Wang

2021

Molecules

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The genus Curculigo, as a folk herbal medicine, has been used for many years in China, treating impotence, limb limpness, and arthritis of the lumbar and knee joints. The last systematic review of the genus Curculigo was written in 2013, scientifically categorizing the phytochemistry and biological activities. Hitherto, the original compounds and their pharmacological activities were presented as the development of this genus, but there is not an updated review. To conclude the progression of the genus Curculigo, we collected the new literature published from 2013 to 2021 in PubMed, Web of Science, Google Scholar databases, and the Chinese National Knowledge Infrastructure. The novel chlorophenolic glucosides, curculigine, phenolic glycosides, orcinosides and polysaccharides were isolated from Curculigo. The new analyzing methods were established to control the quality of Curculigo as a herbal medicine. In addition, the pharmacological effects of Curculigo focused on anti-diabetes, antibacterial, anti-inflammatory, osteoporosis, antioxidation, etc. The antitumor and neuroprotective activities were newly explored in recent years. The application of herbal medicine was gradually developed in scientific methods. The medicinal value of the genus Curculigo needs to further investigate its pharmacological mechanisms. This new review offers more insights into the exploitation of the pharmacological value of the genus Curculigo.

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An O-acetyl-glucomannan from the rhizomes of Curculigo orchioides: Structural characterization and anti-osteoporosis activity in vitro

Cited by 42 publications

References 33 publications

Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis

Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis

Protective effect of the isolated oligosaccharide from Rosa canina in STZ‐treated cells through modulation of the autophagy pathway

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

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