An NMR study of cyclodextrin complexes of the steroidal neuromuscular blocker drug Rocuronium Bromide

Phase solubility and structure of the inclusion complexes of prednisolone and 6α‐methyl prednisolone with various cyclodextrins

“…Looking at the interaction patterns, it is somewhat surprising to see that most of the steroid hydrogen atoms show an interaction with the cavity, because the 1:1 complex formation indicated by the phase‐solubility studies, would lead one to expect only one spatially confined set of interactions. This has also been seen before with steroids and CDs,14,16–20 and is often explained by the presence of a multitude of interaction sites, that can be populated simultaneously or mutually exclusively.…”

“…Numerous studies of the relationship between the structure of the steroids and the stability of their CD complexes have been conducted 8–14. There is also a growing number of structural studies conducted on CD complexes with steroids and steroid‐related molecules in solution 14–20…”

NMR diffusion coefficient study of steroid–cyclodextrin inclusion complexes

“…The data are then fitted to a function that assumes an exchange-averaged value of D obs according to Eqns (1) and (2) The association constants measured in this way are 2600 š 600 l mol 1 for 2-1 and 6000 š 1000 l mol 1 for 3-1 at 298 K. These figures can be compared with the values of K a measured independently by 1 H chemical shift titrations at 303 K (3300 š 500 for 2-1 and 18 000 š 2000 for 3-1). 5 The error ranges quoted for both studies signify the range of values obtained from multiple experiments. We do not understand the poor agreement for complex 3-1.…”

“…for 1 and 4 and 4-1). 5 The diffusion coefficients measured in this way for the compounds 1, 2, 3, 4 and 5 and the complexes 4-1 and 5-1 are listed in Table 1.…”

NMR spectra and dynamics of the sodium salt of per(6-thiobenzoic acid)-γ-cyclodextrin

“…A per-6-substitutedˇ-cyclodextrin has also been shown to have a single twisted glucosyl residue, which allows the self-complexation of a naphthyl moiety (2). 19 The selfcomplexation observed in 2 is attributed to various factors.…”