An NMR-guided approach for identifying co-factors in boosting the Pfu DNA polymerase
Yihao Chen,
Mingjun Zhu,
Xiaoling Zhao
et al.
Abstract:With rapid developments of emerging technologies like synthetic biology, the demand for DNA polymerases with superior activities including higher thermostability and processivity has increased significantly. Thus, rational optimization of the performance of DNA polymerase is of great interest. Nuclear magnetic resonance spectroscopy (NMR) is a powerful technique used for studying protein structure and dynamics. It provides the atomic resolution information of enzymes under its functional solution environment t… Show more
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