An NMDA antagonist impairs copulation and the experience-induced enhancement of male sexual behavior in the rat.

Powell, Whitney S.; Domínguez, Juan M.; Hull, Elaine M.

doi:10.1037/0735-7044.117.1.69

Cited by 37 publications

(31 citation statements)

References 40 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Single (de Jonge et al, 1992) or repeated (Powell et al, 2003) exposures to sexually relevant stimuli facilitate copulatory behavior in males. Our results in Experiment 3 support this finding.…”

Section: Discussionmentioning

confidence: 99%

“…Typically, preexposure to female odors facilitates later sexual performance in naive males (de Jonge, Oldenburger, Louwerse, & van de Poll, 1992;Powell, Dominguez, & Hull, 2003). However, we hypothesized that chronic L-NAME microinjections would block the normal facilitation in sexual performance and render the L-NAME-treated rats inferior copulators compared with saline-treated males and similar to naive rats that were never preexposed to a receptive female.…”

mentioning

confidence: 96%

See 1 more Smart Citation

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Lagoda

Muschamp

Vigdorchik

et al. 2004

Behavioral Neuroscience

Self Cite

View full text Add to dashboard Cite

Dopamine in the medial preoptic area (MPOA) facilitates copulation in male rats, and nitric oxide (NO) regulates basal and female-stimulated MPOA dopamine release. Microinjection of L-nitro-arginine methyl ester (L-NAME, an NO synthesis inhibitor) into the MPOA blocked copulation in naive rats and impaired copulation in sexually experienced males. In other naive rats, L-NAME or saline was microinjected into the MPOA before each of 7 daily exposures to a receptive female placed over their cage. In a drug-free test on Day 8, copulation by L-NAME-treated rats was similar to that of unexposed controls and was impaired relative to saline-treated males. Therefore, NO in the MPOA is important for copulation and stimulus sensitization in male rats.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Lagoda

Muschamp

Vigdorchik

et al. 2004

Behavioral Neuroscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…Glutamate agonists induce erections when injected into the PVN; erections are blocked by injecting glutamate antagonists (Melis et al, 2000;Powell et al, 2003). Glutamate has also been implicated in animal models of female sexual behavior.…”

Section: Discussionmentioning

confidence: 99%

Genetic and Clinical Predictors of Sexual Dysfunction in Citalopram-Treated Depressed Patients

Perlis

Laje

Smoller

et al. 2009

Neuropsychopharmacol

View full text Add to dashboard Cite

Sexual dysfunction is a major contributor to treatment discontinuation and nonadherence among patients treated with selective serotonin reuptake inhibitors (SSRIs). The mechanisms by which depressive symptoms in general, as well as SSRI exposure in particular, may worsen sexual function are not known. We examined genetic polymorphisms, including those of the serotonin and glutamate systems, for association with erectile dysfunction, anorgasmia, and decreased libido during citalopram treatment. Clinical data were drawn from a nested case-control cohort derived from the STAR*D study, a multicenter, prospective, effectiveness trial in outpatients with nonpsychotic major depressive disorder (MDD). Self-reports of erectile dysfunction, decreased libido, or difficulty achieving orgasm based on the Patient-Rated Inventory of Side Effects were examined among Caucasian subjects (n ¼ 1473) for whom DNA and adverse effect measures were available, and who were treated openly with citalopram for up to 14 weeks. Of 1473 participants, 799 (54%) reported decreased libido; 525 (36%) reported difficulty achieving orgasm. Of 574 men, 211 (37%) reported erectile dysfunction. Using a set-based test for association, single nucleotide polymorphisms in glutamatergic genes were associated with decreased libido (GRIA3; GRIK2), difficulty achieving orgasm (GRIA1), and difficulty achieving erection (GRIN3A) (experiment-wide permuted po0.05 for each). Evidence of association persisted after adjustment for baseline clinical and sociodemographic differences. Likewise, evidence of association was similar when the cohort was limited to those who did not report a given adverse event at the first post-baseline visit (ie, those whose adverse events were known to be treatment emergent). These hypothesis-generating analyses suggest the potential for glutamatergic treatment targets for sexual dysfunction during major depressive episodes.

show abstract

“…sexually experienced male rats 6 , but the effect of chronic administration of ketamine on depression induced sexual function was not studied. Therefore, the present study was designed to test the effect of chronic administration of ketamine on depression and sexual function, using forced swim test and sexual behavior study respectively.…”

mentioning

confidence: 99%

“…), neurotransmitters (nitric oxide and dopamine) and ion channels (potassium and calcium) and its role in sexual function. 6,8 …”

mentioning

confidence: 99%

Chronic administration of ketamine induces depression in Wistar rat, but does not affect sexual function

Goswami¹,

Venkata²,

Jaffer³

et al. 2015

JYP

View full text Add to dashboard Cite

An NMDA antagonist impairs copulation and the experience-induced enhancement of male sexual behavior in the rat.

Cited by 37 publications

References 40 publications

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

A Nitric Oxide Synthesis Inhibitor in the Medial Preoptic Area Inhibits Copulation and Stimulus Sensitization in Male Rats.

Genetic and Clinical Predictors of Sexual Dysfunction in Citalopram-Treated Depressed Patients

Chronic administration of ketamine induces depression in Wistar rat, but does not affect sexual function

Contact Info

Product

Resources

About