An n.m.r. and conformational analysis of the terminal trisaccharide from the serologically active glycolipid of Mycobacterium leprae in different solvents

Synthesis of Carbohydrate‐Containing Surface Antigens of Mycobacteria

“…The conformation of compounds 62 was also reported. 43 The (synthesized39 by Fujiwara) against sera from leprosy patients and control showed an obvious similarity: the presence of the innermost sugar did not contribute significantly to sensitivity or specificity. These di-and trisaccharide-containing artificial antigens were found to be suitable for the serodiagnosis of leprosy.…”

Developments in the Synthesis of Mycobacterial Phenolic Glycolipids

“…Since the reported synthesis in 1988 multiple groups have synthesized one or multiple M. leprae PGL glycans [25,54–59] . Líptak and coworkers investigated a new approach towards PGL‐I in 1993 [59] .…”

“…[50][51][52][53] Since the reported synthesis in 1988 multiple groups have synthesized one or multiple M. leprae PGL glycans. [25,[54][55][56][57][58][59] Líptak and coworkers investigated a new approach towards PGL-I in 1993. [59] They set out to reduce the total amount of steps required by concurrently installing multiple methyl ethers in a single step (Scheme 3).…”