An &lt;em&gt;In Vivo&lt;/em&gt; Mouse Model of Total Intravenous Anesthesia During Cancer Resection Surgery

Dubowitz, Julia; Jost-Brinkmann, Fabian; Ziegler, Alexandra I.; Gillis, Ryan D.; Riedel, Bernhard; Sloan, Erica K.

doi:10.3791/62747

Cited by 1 publication

(1 citation statement)

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“…For a long time, there is a lack of validated preclinical models for anesthesia studies, most of which do not use anesthesia itself as the primary endpoint to explore the effects of anesthesia on the tumor itself, the microenvironment and the postoperative prognosis. It is worth mentioning that Dubowitz et al (2021) have successfully replicated key steps in clinical drug administration using propofol-TIVA anesthesia in a mouse model of mastectomy for breast cancer. The successful construction of this model will be of great help in studying…”

Section: Studies Of Propofol In Animal Tumor Modelsmentioning

confidence: 99%

An intravenous anesthetic drug-propofol, influences the biological characteristics of malignant tumors and reshapes the tumor microenvironment: A narrative literature review

Zhou

Shao

et al. 2022

Front. Pharmacol.

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Malignant tumors are the second leading cause of death worldwide. This is a public health concern that negatively impacts human health and poses a threat to the safety of life. Although there are several treatment approaches for malignant tumors, surgical resection remains the primary and direct treatment for malignant solid tumors. Anesthesia is an integral part of the operation process. Different anesthesia techniques and drugs have different effects on the operation and the postoperative prognosis. Propofol is an intravenous anesthetic that is commonly used in surgery. A substantial number of studies have shown that propofol participates in the pathophysiological process related to malignant tumors and affects the occurrence and development of malignant tumors, including anti-tumor effect, pro-tumor effect, and regulation of drug resistance. Propofol can also reshape the tumor microenvironment, including anti-angiogenesis, regulation of immunity, reduction of inflammation and remodeling of the extracellular matrix. Furthermore, most clinical studies have also indicated that propofol may contribute to a better postoperative outcome in some malignant tumor surgeries. Therefore, the author reviewed the chemical properties, pharmacokinetics, clinical application and limitations, mechanism of influencing the biological characteristics of malignant tumors and reshaping the tumor microenvironment, studies of propofol in animal tumor models and its relationship with postoperative prognosis of propofol in combination with the relevant literature in recent years, to lay a foundation for further study on the correlation between propofol and malignant tumor and provide theoretical guidance for the selection of anesthetics in malignant tumor surgery.

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Section: Studies Of Propofol In Animal Tumor Modelsmentioning

confidence: 99%