An L-theanine derivative targets against SARS-CoV-2 and its Delta and Omicron variants

Lü, Jing; Zhang, Ying; Qi, Dan; Yan, Chunyan; Wu, Benhao; Huang, Jason H.; Yao, Jianwen; Wu, Erxi; Zhang, Guoying

doi:10.1016/j.heliyon.2022.e09660

Cited by 2 publications

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NF-κB p65 is one of the main transcription factors stimulating production by peripheral blood mononuclear cells and lung epithelial cells of the pro-inflammatory cytokines, such as IFN, TNFα, etc., which cause pulmonary damages. [44,45,46]…”

Section: Immunologymentioning

confidence: 99%

“…[1] In the United States it was granted a GRAS (generally recognized as safe) status by the FDA. [2] The substance is believed to bring many benefits for both somatic and neuropsychiatric health, examples of the latter being enhancing cognition, focus, sleep quality and relieving anxiety. The goal of this paper is to review the advantages and potential risks of l-theanine supplementation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Benefits of l-theanine supplementation and its possible role in clinical use – review

Womperski,

Woźniak,

Szymonik

et al. 2024

Qual Sport

View full text Add to dashboard Cite

Introduction: Green tea has been a meaningful element of various cultures among the world for ages and its benefits for human health are widely known. Discovery of its ingredients facilitated the profound research of their positive role and mechanisms of action. One of them – l-theanine - seems to have a multidirectional influence on human health. Methods and materials: A review of chosen literature from PubMed database, GoogleScholar database between the years 2000-2023 was conducted using the following keywords: “theanine”, “theanine cognition”, “theanine brain activity”, “theanine neural activity”, “theanine neuroprotection”, “theanine stress”, “theanine cancer”, “theanine immunity”, “theanine safety”, “theanine caffeine”, “theanine metabolism” Aim of study: Review of current knowledge on l-theanine, its benefits for health, mechanisms of action, possible applications in clinical use and safety. Results: L-theanine has a profitable influence on cognitive performance, stress management, neuroprotection, immunity and exhibits anti-cancer properties while having virtually no detrimental side effects. Conclusions: Further research on application of l-theanine in clinical use is necessary as studies carried out on humans included only a limited number of participants.

show abstract

Section: Immunologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Benefits of l-theanine supplementation and its possible role in clinical use – review

Womperski,

Woźniak,

Szymonik

et al. 2024

Qual Sport

View full text Add to dashboard Cite

show abstract

Virtual screening and molecular dynamics simulations provide insight into repurposing drugs against SARS-CoV-2 variants Spike protein/ACE2 interface

Pirolli¹,

Righino²,

Camponeschi³

et al. 2023

Sci Rep

View full text Add to dashboard Cite

After over two years of living with Covid-19 and hundreds of million cases worldwide there is still an unmet need to find proper treatments for the novel coronavirus, due also to the rapid mutation of its genome. In this context, a drug repositioning study has been performed, using in silico tools targeting Delta Spike protein/ACE2 interface. To this aim, it has been virtually screened a library composed by 4388 approved drugs through a deep learning-based QSAR model to identify protein–protein interactions modulators for molecular docking against Spike receptor binding domain (RBD). Binding energies of predicted complexes were calculated by Molecular Mechanics/Generalized Born Surface Area from docking and molecular dynamics simulations. Four out of the top twenty ranking compounds showed stable binding modes on Delta Spike RBD and were evaluated also for their effectiveness against Omicron. Among them an antihistaminic drug, fexofenadine, revealed very low binding energy, stable complex, and interesting interactions with Delta Spike RBD. Several antihistaminic drugs were found to exhibit direct antiviral activity against SARS-CoV-2 in vitro, and their mechanisms of action is still debated. This study not only highlights the potential of our computational methodology for a rapid screening of variant-specific drugs, but also represents a further tool for investigating properties and mechanisms of selected drugs.

show abstract

An L-theanine derivative targets against SARS-CoV-2 and its Delta and Omicron variants

Cited by 2 publications

References 46 publications

Benefits of l-theanine supplementation and its possible role in clinical use – review

Benefits of l-theanine supplementation and its possible role in clinical use – review

Virtual screening and molecular dynamics simulations provide insight into repurposing drugs against SARS-CoV-2 variants Spike protein/ACE2 interface

Contact Info

Product

Resources

About