An Italian survey of opioids misuse: Epidemiological and psychopathological aspects

Stigliano, Gianfranco; Miuli, Andrea; Lalli, Aliseo; Alessi, Maria Chiara; Sociali, Antonella; Esposito, Fabiana; d’Andrea, Giacomo; Mosca, Alessio; Santovito, Maria Chiara; Martinotti, Giovanni; Giannantonio, Massimo Di

doi:10.1016/j.etdah.2021.100029

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…They resulted to be a young population of around 40 years, consistently with a very recent Italian survey conducted from July 2019 to March 2020, that reported a prominent use of opioids in subjects aged between 18 and 40 years. 18 By considering all available periods across the database, nearly 30% of the included PWUDs had a co-diagnosis of HCV. A systematic review by Degenhardt et al reported a worldwide prevalence of injecting drug users in 2015 of 15.6 million people in the age range of 15–64 years, and 52.3% of them resulted HCV-antibody positive.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Patients’ Characteristics and Treatment Profile of People Who Use Drugs (PWUDs) with and without a Co-Diagnosis of Viral Hepatitis C: A Real-World Retrospective Italian Analysis

Nava¹,

Mangia²,

Riglietta³

et al. 2023

TCRM

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Hepatitis C virus (HCV) spreads from contact with blood of an infected person. HCV infections are common among people who use drugs (PWUDs), when sharing needles, syringes, or other equipment for injected drugs. The advent of pangenotypic directantiviral agents (DAA) in 2017 transformed the treatment landscape for HCV, but PWUDs remain a complex and hard-to-treat population with high risk of HCV reinfection. The aim of this real-world analysis was to characterize the demographic and clinical features of PWUDs in Italy, also focusing on comorbidity profile, treatment with DAAs, resource consumptions for the National Health System (NHS). Patients and Methods: During 01/2011-06/2020, administrative databases of Italian healthcare entities, covering 3,900,000 individuals, were browsed to identify PWUDs with or without HCV infection. Among HCV+ patients, a further stratification was made into treated and untreated with DAAs. The date of PWUD or HCV first diagnosis or DAA first prescription was considered as index-date. Patients were then followed-up for one year. Alcohol-dependency was also investigated. Results: Total 3690 PWUDs were included, of whom 1141 (30.9%) PWUD-HCV+ and 2549 (69.1%) PWUD-HCV-. HCV-positive were significantly older (43.6 vs 38.5 years, p < 0.001), had a worse comorbidity profile (Charlson-index: 0.8 vs 0.4, p < 0.001), and high rates of psychiatric, respiratory, dermatological, musculoskeletal diseases and genitourinary (sexually transmitted) infections. Moreover, they received more drug prescriptions (other than DAAs, like anti-acids, antiepileptics, psycholeptics) and had undergone more frequent hospitalization, predominantly for hepatobiliary, respiratory system and mental disorders. DDA-untreated had significantly higher Charlson-index than DAA-treated (0.9 vs 0.6, p = 0.003). Alcoholism was found in 436 (11.8%) cases. Conclusion: This Italian real-world analysis suggests that PWUDs with HCV infection, especially those untreated with DAAs, show an elevated drug consumption due to their complex clinical profile. These findings could help to ameliorate the healthcare interventions on PWUDs with HCV infection.

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Section: Discussionmentioning

confidence: 99%

Analysis of Patients’ Characteristics and Treatment Profile of People Who Use Drugs (PWUDs) with and without a Co-Diagnosis of Viral Hepatitis C: A Real-World Retrospective Italian Analysis

Nava¹,

Mangia²,

Riglietta³

et al. 2023

TCRM

View full text Add to dashboard Cite

show abstract

“…An estimated 62 million people globally used opioids in 2019, and 36.3 million were impacted by their associated problems (UNODC, 2021) [10]. Currently, reports indicate an ongoing upsurge of opioid misuse/abuse, fatal overdose, and other related disorders; in the US has an increasing estimated of 70,029 in 2020 to 80,816 in 2021 [11], in Canada, 7,560 opioidrelated fatalities in 2021 [12], in Italy opioid addiction affects more than ve people per 1000 [13], in Germany a regional study among 57 million adults indicate an opioid prescriptions of 38.7 or 12.8 /1000 persons of low-and high-potency opioids in 2020 [14]. But in low-income impulsivity, improve energy [26], relieve stress [27], peer pressure from friends [28], to engender "morale" and "courage" to engage in sex work and " ght" potentially abusive clients [29].…”

Section: Introductionmentioning

confidence: 99%

The Burden of Unlawful Use of Opioid and Epidemiological Characteristics in Africa: A Scoping Review protocol v1

onohuean

2024

Preprint

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Introduction:There is an ongoing global upsurge of opioid misuse/ abuse, fatal overdose and other related disorders and may be heating hard on the African continent, especially resource limiting sitting due to poor epidemiological surveillance systems. This study aimed to review present studies to provide scientific evidence on epidemiological data on opioid misuse, to highlight the contributing drivers, public health risk factors and reason for use, for effectiveness in control/management and intervention of the brewing opioid crisis in the region. Method: The databases (PubMed, Scopus, Web of Sciences) and references of the included studies will be searched. While theoutcome to be considered includes various studies on the epidemiology or prevalence of opioids, opioids overdose or opioids misuse or opioids abuse or opioid use/addiction or heroin or hydromorphone or hydrocodone or oxycodone ormorphine or codeine or thebaine or paramorphine or fentanyl or pethidine or tramadol or dextropropoxyphene or opioid/ heroin injection or injecting drug. We shall include all types of studies, irrespective of the designs, provided itwas conducted within the African region. However, we intend to exclude titles that dealt with opioids in palliative care or therapeutic opioid use for pain management, studies of substance use in Africa that were not opioid specific, andstudies focused only on epidemiologic estimations methodology as they were not opioid specific. Finally, we shall exclude outside Africa multinational surveys and systematic reviews in favour of original research publications. An analysis of the findings of this study will be presented narratively.

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An Italian survey of opioids misuse: Epidemiological and psychopathological aspects

Cited by 2 publications

References 21 publications

Analysis of Patients’ Characteristics and Treatment Profile of People Who Use Drugs (PWUDs) with and without a Co-Diagnosis of Viral Hepatitis C: A Real-World Retrospective Italian Analysis

Analysis of Patients’ Characteristics and Treatment Profile of People Who Use Drugs (PWUDs) with and without a Co-Diagnosis of Viral Hepatitis C: A Real-World Retrospective Italian Analysis

The Burden of Unlawful Use of Opioid and Epidemiological Characteristics in Africa: A Scoping Review protocol v1

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