An Isomeric Mixture of Conjugated Linoleic Acids But Not Pure cis-9,trans-11-Octadecadienoic Acid Affects Body Weight Gain and Plasma Lipids in Hamsters

Abstract

We report the effect of an atherogenic diet supplemented with cis-9, trans-11-octadecadienoic acid (c9t11), linoleic acid (LA) or an isomeric mixture of conjugated linoleic acids (CLA) on plasma lipids, weight gain and food intake of male Golden Syrian hamsters. Animals were assigned to three diet groups (n = 10), and fed nonpurified diet, supplemented with 10% hydrogenated coconut oil and 0.05% cholesterol for 6 wk. The first diet group was further supplemented with 1% CLA (CLA group), the second diet group with 0.2% c9t11 (c9t11 group) and the third group with 0.2% LA (LA group). The diets were designed to have equivalent levels of c9t11 in the CLA and c9t11 groups. At 2 and 6 wk of feeding, the CLA group had significantly lower plasma triglyceride and total cholesterol concentrations than either the c9t11 or the LA groups. HDL-cholesterol did not differ among diet groups. The CLA group had significantly lower weight gain but greater food intake than either the c9t11 or the LA groups. There were no significant differences between the c9t11 and the LA groups in any of the variables measured. We conclude that under our experimental conditions of short-term feeding, c9t11, thought to be the active compound in CLA, does not produce the same effect as the isomer mixture.

Short-term Administration of Conjugated Linoleic Acid Reduces Liver Triglyceride Concentration and Phosphatidate Phosphohydrolase Activity in OLETF Rats

“…1). Our result on the CLA-induced reduction of serum cholesterol concentration confirms earlier reports, where the dietary CLA-induced reduction of serum cholesterol levels in hamsters and rabbits were reported (Lee et al, 1994;Gavino et al, 2000). Moreover, our result indicates that the short-term administration of CLA can reduce the serum cholesterol concentration in obese diabetic OLETF rats.…”

Adverse effects of conjugated alpha-linolenic acids (CLnA) on lipoprotein profile on experimental atherosclerosis in hamsters

“…These effects were also later shown in rabbits fed a CLA mixture or single CLA isomers (such as RA or 18:2 trans-10, cis-12) provided in a semi-purified diet (Kritchevsky et al, 2004). Similar data were also reported using hamsters (Nicolosi et al, 1997;Gavino et al, 2000;Wilson et al, 2000 andDorfman et al, 2003). CLA may also decrease the formation of fatty streaks in hamsters and rabbits (Lee et al, 1994;Kritchevsky et al, 2004) and may help to attenuate atherosclerosis by inducing apoptosis in the atherosclerotic lesion in mice (Toomey et al, 2006).…”

Non-fat milk solids attenuate hypercholesterolemic effect of conjugated linoleic acid

“…This suggests reduced feed conversion efficiency caused by CLA, as opposed to the previous studies in rats (Chin et al 1994) and pigs (Dugan et al 1997;Ostrowska et al 1999). Our results, however, are consistent with other studies with mice (Degrace et al 2004), hamsters (Gavino et al 2000) and broiler chickens (Badinga et al 2003). The results vary, presumably depending upon the experimental conditions and the animal species used.…”