An isolated cardiac metastasis from colorectal adenocarcinoma

Patel, Meera; Neal, Canyon; Berry, D P; Garcea, G.

doi:10.1136/bcr.08.2010.3270

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…We found only 12 cases of well-documented metastatic CRC that involved the right ventricle of the heart. Table I shows 13 reports including the present case (3,6,9,(19)(20)(21). The median age at presentation in these reports was 71 years (range=35-77 years) with a slight prevalence in female patients (seven patients, 53.8%).…”

Section: ) (F) T1-weighted Magnetic Resonance Imaging (Mri) Showing a Slightly High Intense Mass Measuring 20 MM Compared To The Intact Mmentioning

confidence: 86%

Capecitabine Plus Bevacizumab for Cardiac Metastasis of Sigmoid Colon Cancer: Case Report and Literature Review

Hiroi

Miguchi

Ikeda

et al. 2020

In Vivo

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Background/Aim: Right ventricular cardiac metastasis from colorectal cancer (CRC) is rare and clinically silent. There is no standardised treatment. To date, only twelve cases have been reported in the literature. This is a case report and literature review of right ventricular cardiac metastasis from CRC. Case Report: A 75-year-old woman with a history of CRC treated with sigmoidectomy followed by liver and lung metastasectomy presented with a right ventricle tumour. Biopsy showed metastatic adenocarcinoma not suitable for resection because multiple lung metastases coexisted. The metastases were controlled for a prolonged duration by chemotherapy with capecitabine plus bevacizumab. According to the review of 13 cases, the median age of metastatic CRC that involves the right ventricle is 71 years and the primary site is half the colon and rectum. Half of cases have non-cardiac metastases at cardiac metastasis diagnosis. Chemotherapy is more suitable than resection in cases with metastases other than heart because resection of the right ventricle has a high risk. Conclusion: Cardiac right ventricular metastasis from CRC can be controlled by capecitabine plus bevacizumab.Metastases from colorectal cancer (CRC) can occur either by lymphatic or hematogenous spreading, and the sites most commonly involved are the lymph nodes, liver, and lung.Cardiac metastasis from CRC is an extremely rare event and the incidence is probably underestimated. A large autopsy series reported that colon carcinoma metastases to the heart account for 1.2%, with a prevalence of 2%, of all metastatic neoplasms (1). The reasons for the limited number of reported cases are that cardiac tumours are usually asymptomatic and do not present themselves. A progressive metastatic mass of the heart occasionally causes acute heart failure or superior vena cava syndrome, resulting in sudden death (2, 3). Such masses are often associated with non-specific symptoms, including those of right-sided heart failure, dyspnoea, arrhythmias, pulmonary thromboembolism, and tumour thrombus (4). With regard to the frequency of cardiac metastases from any malignancy, the epicardium (75.5%), followed by the myocardium (38.2%) and endocardium (15.5%) has been reported to be involved (5). In this report, cardiac metastasis refers to the involvement of parts other than the epicardium. Herein, we present a case of a patient with right ventricular cardiac metastasis from adenocarcinoma of the sigmoid colon who was effectively treated with chemotherapy and review reports to date regarding CRC metastases to the right ventricle of the heart, their diagnosis, treatments, and prognosis.

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Section: ) (F) T1-weighted Magnetic Resonance Imaging (Mri) Showing a Slightly High Intense Mass Measuring 20 MM Compared To The Intact Mmentioning

confidence: 86%

Capecitabine Plus Bevacizumab for Cardiac Metastasis of Sigmoid Colon Cancer: Case Report and Literature Review

Hiroi

Miguchi

Ikeda

et al. 2020

In Vivo

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“…9 Due to their asymptomatic nature, diagnosis and treatment can be challenging. 10 In symptomatic cases, they usually present with heart failure including dyspnoea, tachycardia, and edema. 11 We present a case of colon cancer, and due to suspicion of endocarditis symptoms, echocardiography findings led to the discovery of TV metastasis and SVC involvement.…”

Section: Discussionmentioning

confidence: 99%

“…These metastases account for 1.9% of all metastatic neoplasms 9 . Due to their asymptomatic nature, diagnosis and treatment can be challenging 10 . In symptomatic cases, they usually present with heart failure including dyspnoea, tachycardia, and edema 11 .…”

Section: Discussionmentioning

confidence: 99%

Superior vena cava and tricuspid valve tumoral thrombosis in a 54‐year‐old female with metastatic colorectal adenocarcinoma: A rare case report

Mostafavi,

Nabati,

Vahedi Larijani

et al. 2023

Sonography

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“…The cardiac metastasis mechanism is thought to be as follows: (a) direct extension: Klatt and Heitz [ 23 ] suggested that as the lungs are close to the heart, metastases can reach the heart directly; (b) hematogenous spread: Patel et al [ 24 ] reported the ability of tumor embolization to invade the heart through the portal circulation via the vena cava and liver without seeding into it; and (c) lymphatic spread: Mukai et al [ 2 ] suggested that intralymphatic retrograde metastasis due to mediastinal lymph node metastasis was the major pathway in gastrointestinal cancer.…”

Section: Discussion/conclusionmentioning

confidence: 99%