An isoflavone enriched diet increases skeletal muscle adaptation in response to physical activity in ovariectomized rats

Abstract

Our results indicate that the combination of ISOs and exercise is more efficient in increasing relative skeletal muscle mass and the expression of molecular markers related to anabolic adaptation in the skeletal muscle of female rats.

Anabolic Activity of a Soy Extract and Three Major Isoflavones in C2C12 Myotubes

“…In rat L6 skeletal muscle cells, genistein promoted cells proliferation at doses ≤ 1 µM, which is in agreement with our datademonstrating a stimulation of protein synthesis in C2C12 myotubes at the same dose [16]. Our data are also in line with our previous in vivo studies demonstrating that isoflavones increased soleus muscle weight in ovariectomized female rats [17,18]. Interestingly, our investigations also demonstrate that treatment with E2, SoyEx, isoflavones, and Mix resulted in a higher number of myotubes per area compared to the control cells (▶ Fig.…”

Influence of Fermented Red Clover Extract on Skeletal Muscle in Early Postmenopausal Women: A Double-Blinded Cross-Over Study

“…ER-β is expressed and localized within skeletal muscle tissue [ 21 ], and ER-β activation appears to regulate signaling pathways important for skeletal muscle growth and regeneration [ 22 ]. In animals, a number of studies have investigated the influence of isoflavones found in soy (mainly genistein and daidzein) on skeletal muscle [ 23 , 24 , 25 , 26 ]. The results are promising, showing reduced muscle atrophy [ 23 , 24 ], lower expression of ubiquitin-specific protease 19 through ER-β activation [ 25 ], and an improved anabolic response to training in rats, accompanied by higher expression of myogenic regulatory factors [ 26 ].…”

Identification of a Novel Function of Resveratrol and Genistein as a Regulator of β2‐Adrenergic Receptor Expression in Skeletal Muscle Cells and Characterization of Promoter Elements Required for Promoter Activation

“…This suggests that a significant increase in the IGF‐1 mRNA levels might require increased β 2 ‐AR expression along with a supply of its ligand. Since the ER agonist activity of isoflavones is widely acknowledged to contribute to increasing muscle mass and preventing atrophy, multiple activities of GEN in addition to increasing β 2 ‐AR gene expression may be involved in improving skeletal muscle mass.…”