An analysis methodology for filament wound composite overwrapped pressure vessels (COPVs) is summarized. The COPV finite element model is generated from an in-house pre-processing code, which is able to model the variation of the fiber orientation from boss to boss, include the thickness of each ply throughout the vessel, and represent the orthotropic properties of the ply on an individual basis. The residual stresses from manufacturing are accounted for by modeling the autofrettage process using the Abaqus finite element software. Finally, a user subroutine was implemented to simulate failure progression from the presence of an incipient defect. As an illustrative example, finite element analysis is used to determine the structural integrity of a COPV due to a delamination initiatiating in ply drop-off regions.