An irradiation facility with a vertical beam for radiobiological studies

Besserer, Jürgen; Boer, J. de; Dellert, M.; Gahn, C.; Moosburger, M.; Pemler, P.; Quicken, P.; Distel, Luitpold; Schüßler, H.‐D.

doi:10.1016/s0168-9002(99)00195-3

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…25 µm thick kapton foils have already been used in radiobiological studies for beam exit windows of up to 60 mm in diameter which is easily sufficient to cover the planned field size of 30 mm × 30 mm. 35 Nevertheless, both a 25 and a 125 µm thick kapton window are investigated as extraction windows with respect to the lateral propagation of the proton minibeam at the focal point. In addition, the lateral spread from a dosimetry unit and from the protons traversing through air is considered.…”

Section: C1 Beam Extractionmentioning

confidence: 99%

Magnetically focused 70 MeV proton minibeams for preclinical experiments combining a tandem accelerator and a 3 GHz linear post‐accelerator

Mayerhofer

Datzmann

Degiovanni³

et al. 2021

Medical Physics

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Purpose: Radiotherapy plays an important role for the treatment of tumor diseases in two-thirds of all cases, but it is limited by side effects in the surrounding healthy tissue. Proton minibeam radiotherapy (pMBRT) is a promising option to widen the therapeutic window for tumor control at reduced side effects. An accelerator concept based on an existing tandem Van de Graaff accelerator and a linac enables the focusing of 70 MeV protons to form minibeams with a size of only 0.1 mm for a preclinical small animal irradiation facility, while avoiding the cost of an RFQ injector. Methods: The tandem accelerator provides a 16 MeV proton beam with a beam brightness of B ¼ 4 nA mm 2 mrad 2 as averaged from 5 µs long pulses with a flat top current of 17 µA at 200 Hz repetition rate. Subsequently, the protons are accelerated to 70 MeV by a 3 GHz linear post-accelerator consisting of two Side Coupled Drift Tube Linac (SCDTL) structures and four Coupled Cavity Linac (CCL) structures [design: AVO-ADAM S.A (Geneva, Switzerland)]. A 3 GHz buncher and four magnetic quadrupole lenses are placed between the tandem and the post-accelerator to maximize the transmission through the linac. A quadrupole triplet situated downstream of the linac structure focuses the protons into an area of (0.1 × 0.1) mm 2 . The beam dynamics of the facility is optimized using the particle optics code TRACE three-dimensional (3D). Proton transmission through the facility is elaborated using the particle tracking code TRAVEL. Results: A study about buncher amplitude and phase shift between buncher and linac is showing that 49% of all protons available from the tandem can be transported through the post-accelerator. A mean beam current up to 19 nA is expected within an area of (0.1 × 0.1) mm 2 at the beam focus. Conclusion: An extension of existing tandem accelerators by commercially available 3 GHz structures is able to deliver a proton minibeam that serves all requirements to obtain proton minibeams to perform preclinical minibeam irradiations as it would be the case for a complete commercial 3 GHz injector-RFQ-linac combination. Due to the modularity of the linac structure, the irradiation facility can be extended to clinically relevant proton energies up to or above 200 MeV.

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Section: C1 Beam Extractionmentioning

confidence: 99%

Magnetically focused 70 MeV proton minibeams for preclinical experiments combining a tandem accelerator and a 3 GHz linear post‐accelerator

Mayerhofer

Datzmann

Degiovanni³

et al. 2021

Medical Physics

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“…Basic studies in radiobiology and particularly survival fraction studies, are performed at doses ranging from 0.1 to 10 Gy [3,7,[14][15][16][17] and with a dose rate ranging from 0.1 to 10 Gy/min. This range of dose rates also allows us to study low dose rates and low dose hypersensitivity [17][18][19].…”

Section: Dose and Dose Rate Assessmentmentioning

confidence: 99%

Preliminary results of proton beam characterization for a facility of broad beam in vitro cell irradiation

Wéra

Donato

Michiels

et al. 2008

Nuclear Instruments and Methods in Physics Research Section B:

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“…However, microbeam installation requires tedious developments for cell recognition, alignment and beam scanning. On the other hand, broad beams are easier to implement [17][18][19][20][21][22]. Furthermore, this system also allows simultaneous treatment of thousands of cells within minutes.…”

Section: Introductionmentioning

confidence: 99%