An Iranian herbal‐marine medicine, MS₁₄, ameliorates experimental allergic encephalomyelitis

Abstract

Multiple sclerosis is an inflammatory and demyelinating disease of the central nervous system which mainly affects young adults. To overcome wide spectrum troublesome symptoms of multiple sclerosis which affects the quality of life both in patients and their families, new drugs and remedies have been examined and offered. The preclinical beneficial effects of different medicines have mostly been examined in an animal model of multiple sclerosis called experimental allergic encephalomyelitis (EAE). In this study we have tested a traditionally used natural (herbal-marine) product called MS(14) in EAE mice. EAE mice were fed with MS(14) containing diet (30%) on the immunization day and monitored for 20 days. The results show that while clinical scores and therefore severity of the disease was progressive in normal-fed EAE mice, the disease was slowed down in MS(14)-fed EAE mice. Moreover, while there were moderate to severe neuropathological changes in normal fed mice, milder changes were seen in MS(14) fed mice.

MS14, a Marine Herbal Medicine, an Immunosuppressive Drug in Experimental Autoimmune Encephalomyelitis

“…Identification of new anti-inflammatory agents to enhance axon myelination would present new therapeutic approaches to inhibit and possibly reverse the disease progression (27, 28). Our findings indicated that herbal drugs diminished the neurological signs of EAE, which was supported by prior studies (19, 29). MS14 as an anti-inflammatory remedy decreased T-cell proliferation and proinflammatory cytokines levels.…”

“…All animals were housed separately in each cage and MS14 was administrated to the treatment group orally. They were also fed with MS14-containing (30 %) diet from the day of immunization (19) to the end of the study.…”

“…The purpose of this study was to examine the MS14 effects (18, 19) on clinical parameters including the IL-6 level in well-established animal models of MS (EAE), in experimental and control groups.…”

MS14 Down-regulates Lipocalin2 Expression in Spinal Cord Tissue in an Animal Model of Multiple Sclerosis in female C57BL/6

“…Animals in treated group received food containing MS14 (30% of food weight) from the day of immunization to the end of the study. MS14 powder was a gift from Pharmacology Department of Shahed University by decedent Dr. Amrollah Ahmadi [12]. …”

“…It has anti-inflammatory and immunomodulatory effects through reduction of TNF-α and IL-1β production in MS and EAE [10]. Due to these anti-inflamatory effects it is considered as a potential therapy for MS [11, 12]. However, effects of MS14 on oxidative stress and the mechanisms underlying regulates the immune system remain unknown.…”