An Ir(III) complex chemosensor for the detection of thiols

Abstract

In this study, we report the use of a cyclometalated luminescent iridium(III) complex for the visualization of thiols. The detection of glutathione (GSH) by complex 1 is achieved through the reduction of its phendione N^N donor, which influences the metal-to-ligand charge-transfer (MLCT) of the complex. Complex 1 produced a maximum threefold luminescence enhancement at 587 nm in response to GSH. The linear detection range of 1 for GSH is between 0.2 and 2 M equivalents of GSH, with a detection limit of 1.67 μM. Complex 1 also displays good selectivity for thiols over other amino acids.

Luminescent chemosensors by using cyclometalated iridium(iii) complexes and their applications

“…10a ). 65 Reducing the phendione N^N donor by GSH is predicted to strongly affect the LUMO of the iridium( iii ) complex. This alters the absorption and emission properties of iridium( iii ) complex, thus allowing 10 to serve as a luminescent probe for thiol detection.…”

Self-assembly as a key player for materials nanoarchitectonics

“…By analogy with computational optimizations of efficiency and function of novel cyber technologies such as machine learning [1][2][3][4][5], the optimization of structure, combination, and organization of materials towards advanced functionality based on accumulated knowledge, theories, facts, experiences, and intuitions must continue [6][7][8][9]. Current societal demands including materials synthesis and production [10][11][12][13][14], energy storage and conversion [15][16][17][18][19][20][21][22], analyte sensing and detection [23][24][25][26], environmental remediation [27][28][29][30], and biological and biomedical applications [31][32][33][34][35][36] are currently being met through developments in the science and technology of advanced materials.…”

Novel Long-Lifetime Iridium Complex as Lab-on-a-Molecule for Hg2+ and pH-Activatable Probes

“…However, a fluorescence signal of organic molecules is prone to interference by scattering and autofluorescence when the technique is applied to multicomponent detection. , A feasible method to overcome this problem is to replace the fluorescence with a long-lifetime phosphorescence signal which can be distinguished from a strongly autofluorescent background using time-resolved luminescence spectroscopy. In this respect, many iridium complexes are applied for biological detection and cell imaging analysis. − For example, Mao et al developed a long-lifetime switch-on iridium­(III) chemosensor for the visualization of cysteine in live zebrafish . Zheng et al prepared an iridium-complex-based nanosensor, which was a powerful tool for the diagnosis of cancer metastasis .…”