An Ionic Liquid-Based Green Synthesis Strategy: Synthesis of Dihydropyrimidinones by Three-Component Biginelli-Type Reaction of Aliphatic Aldehydes, Aromatic Aldehydes and Urea
Abstract:A Biginelli-type reaction involving aliphatic aldehydes, aromatic aldehydes, and urea was performed at high concentration with high regioselectivity to give a range of highly diverse 3,4-dihydropyrimidin-2-(1H)-one products in 58-88% yields, where a 30% aqueous solution of ionic liquid (1-ethyl-3-methylimidazolium tetrafluoroborate) was employed as a green reaction medium. The catalyst can be easily recycled
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