An Ion Concentration Polarization Microplatform for Efficient Enrichment and Analysis of ctDNA
Zhiying Wang,
Ming Liu,
Haocheng Lin
et al.
Abstract:Strategies for rapid, effective nucleic acid processing hold tremendous significance to the clinical analysis of circulating tumor DNA (ctDNA), a family of important markers indicating tumorigenesis and metastasis. However, traditional techniques remain challenging to achieve efficient DNA enrichment, further bringing about complicated operation and limited detection sensitivity. Here, we developed an ion concentration polarization microplatform that enabled highly rapid, efficient enrichment and purification … Show more
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