An Invitro Study on Eugenia Jambolanaplant Extractin Isolated Rabbit Ilium Showing Spasmolytic Effects

Riaz, Muhammad Naeem

doi:10.21065/19257430.4.1

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…In addition to these, spasmolytic activity and the probable mechanism of action in smooth muscle, have been investigated with extracts from the seeds, fruits and leaves of the species S. cumini [23][24][25][26][27]. In this context, this work aimed to continue the investigation of spasmolytic activity, presenting unpublished results of the effect of the hydroalcoholic extract obtained from the seeds of S. cumini on segments of the smooth muscle (uterus, jejunum, aorta and trachea) isolated of rat, as well as hypothesis of a possible spasmolytic mechanism of action.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Profile and Investigation of the Spasmolytic Activity of Hydroalcoholic Extract of Syzygium cumini (L.) Skeels Seeds

Monteiro

Carvalho

Ribeiro

et al. 2020

EJMP

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Aims: Perform the phytochemical analysis and investigate the spasmolytic activity of the hydroalcoholic extract obtained from S. cumini seeds (EHS-SC). Study Design: Qualitative phytochemical analysis and test of the EHS-SC on isolated smooth muscles (aorta, trachea, jejunum and uterus) of rat, to value effect relaxant and/or inhibitor. Place and Duration Methodology: EHS-SC was submitted to phytochemical analysis and changes in color, fluorescence and absence or presence of precipitate were observed. The smooth muscle segments were suspended (tension of 1 g) in glass vats containing specific saline solution, at an appropriate temperature and after stabilization period, was stimulated by a suitable contractile agent to observe the effect of EHS-SC in the phasic and/or tonic component. Original ResearchArticle the CCh to 82.9 ± 10.5; 67.6 ± 6.0 and 10.1 ± 8.3%. Conclusion: Spasmolytic activity may be combined with antimicrobial and antidiarrheal activity according to literature data, where they show that the seeds have the same secondary metabolites, signaling the therapeutic potential for the treatment of colic and/or diarrhea. The upward arrow represents the addition of CCh (carbachol). The down arrows represent the concentrations of nsion); min (minutes); W = washPeer-review history: The peer review history for this paper can be accessed here:

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Section: Introductionmentioning

confidence: 99%

Phytochemical Profile and Investigation of the Spasmolytic Activity of Hydroalcoholic Extract of Syzygium cumini (L.) Skeels Seeds

Monteiro

Carvalho

Ribeiro

et al. 2020

EJMP

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Solid‐State NMR‐Driven Crystal Structure Prediction of Molecular Crystals: The Case of Mebendazole

Bravetti

Bordignon

Alig

et al. 2021

Chemistry A European J

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Among all possible NMR crystallography approaches for crystal-structure determination, crystal structure prediction -NMR crystallography (CSP-NMRX) has recently turned out to be a powerful method. In the latter, the original procedure exploited solid-state NMR (SSNMR) information during the final steps of the prediction. In particular, it used the comparison of computed and experimental chemical shifts for the selection of the correct crystal packing. Still, the prediction procedure, generally carried out with DFT methods, may require important computational resources and be quite time-consuming, especially if there are no available constraints to use at the initial stage. Herein, the successful application of this combined prediction method, which exploits NMR information also in the input step to reduce the search space of the predictive algorithm, is presented. Herein, this method was applied on mebendazole, which is characterized by desmotropism. The use of SSNMR data as constraints for the selection of the right tautomer and the determination of the number of independent molecules in the unit cell led to a considerably faster process, reducing the number of calculations to be performed. In this way, the crystal packing was successfully predicted for the three known phases of mebendazole. To evaluate the quality of the predicted structures, these were compared to the experimental ones. The crystal structure of phase B of mebendazole, in particular, was determined de novo by powder diffraction and is presented for the first time in this paper.

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An Invitro Study on Eugenia Jambolanaplant Extractin Isolated Rabbit Ilium Showing Spasmolytic Effects

Cited by 2 publications

References 18 publications

Phytochemical Profile and Investigation of the Spasmolytic Activity of Hydroalcoholic Extract of Syzygium cumini (L.) Skeels Seeds

Phytochemical Profile and Investigation of the Spasmolytic Activity of Hydroalcoholic Extract of Syzygium cumini (L.) Skeels Seeds

Solid‐State NMR‐Driven Crystal Structure Prediction of Molecular Crystals: The Case of Mebendazole

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