An investigational tetravalent meningococcal serogroups A, C, W-135 and Y-tetanus toxoid conjugate vaccine co-administered with Infanrix™ hexa is immunogenic, with an acceptable safety profile in 12–23-month-old children

Meningococcal Vaccines

“…MenACWY-TT aşısının çocuk, adolesan, erişkin ve 55-103 yaş arası popülasyonda da immünojenik ve güvenilir olduğu yapılan çalışmalarda gösterilmiştir (25)(26)(27)(28)(29)(30)(31)(32)(33)(34) . Baxter ve ark.…”

Meningococcal quadrivalent tetanus toxoid conjugate vaccine (MenACWY-TT, Nimenrix™): A review of its immunogenicity, safety, co-administration, and antibody persistence

“…67 Co-administration with DTaP-HepB-IPV/Hib(Infanrix-hexa TM , GlaxoSmithKline) In a phase III randomized trial that enrolled healthy toddlers in their second year of life from 72 centers in Germany, Austria and Greece. 68 Subjects were randomized into four groups to either receive both MenACWY-TT and DTaP-HepB-IPV/Hib on the same day, or MenACWY-TT followed by DTaP-HepB-IPV/Hib (ACWY/Hexa) one month later, or DTaP-HepB-IPV/ Hib initially followed by MenACWY-TT (Hexa/ACWY) a month later, or a single dose of MenC-CRM197 (Meningitec TM , Pfizer). Co-administration of both vaccines was shown to be non-inferior to administering either alone, with the number of subjects with rSBA titers 1:8 reached above the predefined limit for all serogroups, and there was no difference in terms of hepatitis B, Hib, diphtheria, tetanus, and polio immunogenicity.…”

Universal protein vaccines againstNeisseria meningitidisserogroup B,Streptococcus pneumoniaeand influenza

“…7 Fortunately, those due to A, C, Y and W135 can be efficiently prevented even in younger patients by vaccines including specific conjugated capsular polysaccharides. 8,9 However, a group B capsular polysaccharide cannot be used to prepare a specific vaccine against the invasive disease caused by serogroup B because its close structural similarity to the glycosyl residues present on host cell proteins such as neural cell adhesion molecules (NCAM) means that it is tolerated by the immune system, and its administration could induce autoimmunity. 10 As N. meningitidis group B infection accounts for most cases of invasive meningococcal disease in Europe, Americas, Australia ©2 0 1 1 L a n d e s B i o s c i e n c e .…”