An investigation on the stability of n-D Lur'e systems

Investigation of the maternal to foetal serum concentration gradient of dexamethasone in the rat

“…In conclusion, the present study provides evidence of an active placental elimination of dexamethasone from the foetal to maternal side in the rat. Clinical reports of lower concentrations of dexamethasone (Kream et al, 1983), methylprednisolone (Anderson et al, 1981), betamethasone (Ballard et al, 1975) and certain antibiotics (see, Duignan et al, 1973) in the cord than in the maternal blood could also be indicative of a similar active placental transfer mechanism, provided these concentration differences are not reflections of relatively lower protein binding in the foetal blood. If an active placental transfer mechanism does exist in humans, it can be a potential site of interaction between certain types of drugs.…”