An investigation on the radiation sensitivity of DNA conformations to 60Co gamma rays by using Geant4 toolkit

Semsarha, Farid; Goliaei, Bahram; Raisali, Gholamreza; Khalafi, H.; Mirzakhanian, Lalageh

doi:10.1016/j.nimb.2014.01.002

Cited by 16 publications

(9 citation statements)

References 58 publications

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“…Also, by using the Geant4-DNA extension, the Geant4 toolkit can be utilized for simulation of early biological damage induced by ionizing radiation at micrometric and nanometric scale such as DNA [28,29]. Capability of the Geant4-DNA in microdosimetry and nanodosimetry fields has been investigated in some previous studies [30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Calculation of direct effects of 60Co gamma rays on the different DNA structural levels: A simulation study using the Geant4-DNA toolkit

Tajik

Rozatian

Semsarha

2015

Nuclear Instruments and Methods in Physics Research Section B:

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Section: Introductionmentioning

confidence: 99%

Calculation of direct effects of 60Co gamma rays on the different DNA structural levels: A simulation study using the Geant4-DNA toolkit

Tajik

Rozatian

Semsarha

2015

Nuclear Instruments and Methods in Physics Research Section B:

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“…This cylindrical approach was also followed by Semsarha and colleagues for the prediction of DNA damage in a variety of studies: from Auger emitter radionuclides ( 123 I and 125 I) [54], from 60 Co gamma rays [55,56] and from ultrasoft X-rays [57].…”

Section: The Cylinder Volumes Approachmentioning

confidence: 99%

“…The first study investigated the influence of DNA conformation of strand break yields [55]. The three B-, A-and Z-DNA conformations were studied for 34 bp segments of DNA, including the B-DNA description based on the earlier work by Charlton and Humm [59].…”

Section: The Cylinder Volumes Approachmentioning

confidence: 99%

Review of Geant4-DNA applications for micro and nanoscale simulations

et al. 2016

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Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-byevent electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis. Since its release, Geant4-DNA has been adopted as an investigational tool in kV and MV external beam radiotherapy, hadron therapies using protons and heavy ions, targeted therapies and radiobiology studies. It has been benchmarked with respect to other track structure Monte Carlo codes and, where available, against reference experimental measurements. While Geant4-DNA physics models and radiolysis modelling functionalities have already been described in detail in the literature, this review paper summarises and discusses a selection of representative papers with the aim of providing an overview of a) geometrical descriptions of biological targets down to the DNA size, and b) the full spectrum of current micro-and nano-scale applications of Geant4-DNA. Disciplines Engineering | Science and Technology Studies Publication DetailsIncerti, S., Douglass, M., Penfold, S., Guatelli, S. & Bezak, E. (2016). Review of Geant4-DNA applications for micro and nanoscale simulations. Physica Medica: an international journal devoted to the applications of physics to medicine and biology, 32 (10), 1187-1200. AbstractEmerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis.

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“…Semsarha et al [ 17 ] have recently published a study on the influence of DNA conformation on strand break yields after 60 Co irradiation, including direct and indirect effects, although the latter has been roughly accounted for. They included the A-, B-, and Z-DNA forms and also determined microdosimetric quantities such as the mean specific imparted energy.…”

Section: Introductionmentioning

confidence: 99%

The Influence of DNA Configuration on the Direct Strand Break Yield

Bernal

deAlmeida

Incerti

et al. 2015

Computational and Mathematical Methods in Medicine

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Purpose. To study the influence of DNA configuration on the direct damage yield. No indirect effect has been accounted for. Methods. The GEANT4-DNA code was used to simulate the interactions of protons and alpha particles with geometrical models of the A-, B-, and Z-DNA configurations. The direct total, single, and double strand break yields and site-hit probabilities were determined. Certain features of the energy deposition process were also studied. Results. A slight increase of the site-hit probability as a function of the incident particle linear energy transfer was found for each DNA configuration. Each DNA form presents a well-defined site-hit probability, independently of the particle linear energy transfer. Approximately 70% of the inelastic collisions and ~60% of the absorbed dose are due to secondary electrons. These fractions are slightly higher for protons than for alpha particles at the same incident energy. Conclusions. The total direct strand break yield for a given DNA form depends weakly on DNA conformation topology. This yield is practically determined by the target volume of the DNA configuration. However, the double strand break yield increases with the packing ratio of the DNA double helix; thus, it depends on the DNA conformation.

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An investigation on the radiation sensitivity of DNA conformations to 60Co gamma rays by using Geant4 toolkit

Cited by 16 publications

References 58 publications

Calculation of direct effects of 60Co gamma rays on the different DNA structural levels: A simulation study using the Geant4-DNA toolkit

Calculation of direct effects of 60Co gamma rays on the different DNA structural levels: A simulation study using the Geant4-DNA toolkit

Review of Geant4-DNA applications for micro and nanoscale simulations

The Influence of DNA Configuration on the Direct Strand Break Yield

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