An Investigation on the Antimicrobial Activity of Andrographis paniculata Extracts and Andrographolide in vitro

Xu, Youhong; Marshall, L.; Mukkur, K S Trilochan

doi:10.3923/ajps.2006.527.530

Cited by 37 publications

(2 citation statements)

References 11 publications

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“…Based on the abundant bioactive constituents, APN showed many salutary effects, such as anticancer [12], hepatoprotective [13], antiviral [14, 15], antipyretic and analgesic [16] effects, etc . Interestingly, the immunomodulatory [17], antioxidant [18], anti-inflammatory [19] and antimicrobial [20, 21] activities of APN were also reported, which may suggest the clinical use of APN in treatment for PID. Besides, APN is the principal constituent in a famous traditional Chinese medicine Fukeqianjin tablet which is used to treat PID.…”

Section: Introductionmentioning

confidence: 99%

The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway

Zou

Xiao

Wen

et al. 2016

BMC Complement Altern Med

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Background Andrographis paniculata (Burm. f.) Nees (APN), a principal constituent of a famous traditional Chinese medicine Fukeqianjin tablet which is used for the treatment of pelvic inflammatory disease (PID), has been reported to have anti-inflammatory effect in vitro. However, whether it has pharmacological effect on PID in vivo is unclear. Therefore, the aim of this study is to test the anti-inflammatory effect of APN and illuminate a potential mechanism.MethodsThirty-six female specific pathogen-free SD rats were randomly divided into control group, PID group, APN1 group, APN2 group, APN3 group and prednisone group. Pathogen-induced PID rats were constructed. The APN1, APN2 and APN3 group rats were orally administrated with APN extract at different levels. The prednisone group rats were administrated with prednisone. Eight days after the first infection, the histological examination of upper genital tract was carried out, and enzyme-linked immunosorbent assay (ELISA) was carried out using homogenate of the uterus and fallopian tube. Furthermore, immunohistochemical evaluations of NF-κB p65 and IκB-α in uterus was conducted.ResultsAPN obviously suppressed the infiltrations of neutrophils and lymphocytes, and it could significantly reduce the excessive production of cytokines and chemokines including IL-1β, IL-6, CXCL-1, MCP-1 and RANTES in a dose-dependent manner. Furthermore, APN could block the pathogen-induced activation of NF-κB pathway.ConclusionAPN showed potent anti-inflammatory effect on pathogen-induced PID in rats, with a potential mechanism of inhibiting the NF-κB signal pathway.

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Section: Introductionmentioning

confidence: 99%

The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-κB pathway

Zou

Xiao

Wen

et al. 2016

BMC Complement Altern Med

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“…Ethanolic and aqueous extract of A. paniculata was investigated for its antimicrobial activity against nine bacterial species including Salmonella typhimurium, Escherichia coli, Shigella sonnei, Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumoniae, Streptococcus pyogenes, Legionella pneumophila and Bordetella pertussis. Of all tested concentrations, the plant showed activity against L. pneumophila and B. pertussi 8 . The antibacterial studies of methanolic extract of Murraya koenigii leaf confirmed its effectiveness for S.typhi and E.coli at 100 μg/ ml resulting in moderate zone of inhibition 9 .…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Medicinal Plants and Their Pharmacological Aspects

Singh,

Sedha

2016

Food & Pharma Intl.

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This review focuses on the various pharmacological activities and properties possessed by the medicinal plants in general as well as the advantages and disadvantages of herbal medicines. Plants have been the traditional source of raw materials for medicines since long time. These medicinal properties are due to their content known as phytochemicals. The basic uses of plants in medicine will continue in the coming future as a source of therapeutic agents and as basic raw material for cosmetics, perfumes and food industries.

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