An Investigation on Freshwater Fish Oreochromis niloticus (Linnaeus, 1758): Assessing Hemotoxic Effects of Different Copper Compounds Used as Nanomaterial or Pesticide

Fırat, Özgür; Erol, Rabia

doi:10.1007/s00128-021-03320-6

Cited by 4 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the TEM images reflected that synthesized CuO NPs were spherical and had a uniform size of less than 50 nm. Their spherical shape and uniform size were previously observed by Jahan et al ( 2021 ) and Fırat et al ( 2022a , b ). The presence of bright circular spots was detected in the present SAED profiles of (GS and CS) CuO NPs.…”

Section: Discussionsupporting

confidence: 70%

Is the trend toward a sustainable green synthesis of copper oxide nanoparticles completely safe for Oreochromis niloticus when compared to chemical ones?: using oxidative stress, bioaccumulation, and histological biomarkers

Badran,

Hamed

2024

Environ Sci Pollut Res

View full text Add to dashboard Cite

Scientists worldwide have noticed that cutting-edge technologies can be used to produce nanoparticles (NPs) in a sustainable and environmentally friendly way, instead of the old methods. However, the effectiveness of this approach for aquatic environments and species still needs to be determined. Therefore, this study aims to compare between the toxicity of green and chemically synthesized copper oxide nanoparticles (GS and CS) CuO NPs at two different concentrations on Nile tilapia (Oreochromis niloticus) using various biomarkers. CuO NPs’ formation was proved, and their different characterizations were recorded. Then, the fish samples were randomly allocated in glass aquaria into five groups: one acted as a control group, and the other groups were exposed to two concentrations (25 and 50 mg/L) of GS-CuO NPs and CS-CuO NPs, separately, for 4 days. After the experimental time, in all groups that were exposed to two concentrations of both synthesized CuO NPs, the results revealed that glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and thiobarbituric acid reactive substances (TBARS) levels were elevated in the liver and gills compared to glutathione reduced (GSH) content, which showed a significant decline. Bioaccumulation of Cu was more prevalent in the liver than in the gills, and the highest bioaccumulation capacity was more evident in the groups exposed to CS-CuO NPs. Moreover, the bioaccumulation of Cu caused severe histological changes in the liver and gills. In conclusion, the results suggested that GS-CuO NPs revealed less toxicity than CS-CuO NPs to the examined fish. However, they are still toxic, and their toxic effect cannot be overlooked.

show abstract

Section: Discussionsupporting

confidence: 70%

Is the trend toward a sustainable green synthesis of copper oxide nanoparticles completely safe for Oreochromis niloticus when compared to chemical ones?: using oxidative stress, bioaccumulation, and histological biomarkers

Badran,

Hamed

2024

Environ Sci Pollut Res

View full text Add to dashboard Cite

show abstract

“…However, erythrocytes (4.83 ± 0.18 vs. 3.09 ± 0.05 × 10 6 /mm 3 ), hematocrit (34.14 ± 2.39 vs. 24.70 ± 0.58 %), and hemoglobin (8.96 ± 0.23 vs. 6.91 ± 0.18 g.dL −1) , and lymphocytes (18.61 ± 0.54 vs. 14.85 ± 0.16 %) were decreased significantly ( p < 0.05) after the exposure to CuSO 4 (0.28 μg.L −1 ) on all experimental days. Similarly, CuSO 4 (0.05 mg/L) exposure to fish Oreochromis niloticus had been reported to significantly ( p < 0.05) decrease erythrocytes (1.78 ± 0.03 vs. 1.41 ± 0.02 10 6 /μL), hematocrit (31.95 ± 0.74 vs. 24.83 ± 0.37 %), and hemoglobin (8.38 ± 0.09 vs. 5.94 ± 0.12 g/dL) values ( 17 ). It is also on record that CuSO 4 -NPs render more reduction in these parameters than CuSO 4 itself ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, CuSO 4 (0.05 mg/L) exposure to fish Oreochromis niloticus had been reported to significantly ( p < 0.05) decrease erythrocytes (1.78 ± 0.03 vs. 1.41 ± 0.02 10 6 /μL), hematocrit (31.95 ± 0.74 vs. 24.83 ± 0.37 %), and hemoglobin (8.38 ± 0.09 vs. 5.94 ± 0.12 g/dL) values ( 17 ). It is also on record that CuSO 4 -NPs render more reduction in these parameters than CuSO 4 itself ( 17 ). The lower hematological values in this study might be due to hemoglobin oxidation, erythrocyte destruction, and hemolysis ( 23 , 47 , 53 , 56 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Copper sulfate induces clinico-hematological, oxidative stress, serum biochemical and histopathological changes in freshwater fish rohu (Labeo rohita)

Naz

Hussain²,

Guangbin³

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

Despite being an essential trace element for numerous metabolic processes and micronutrients, copper (Cu) has induced adverse effects on the environment and public health due to its continuous and widespread use for the last several decades. The current study assessed the hematological and histopathological alterations in the freshwater fish (Labeo rohita) exposed to graded concentrations of copper sulfate. For this purpose, L. rohita fish (n = 72), weighing ~200–215 g, were randomly divided into four experimental groups and then exposed to acute doses of CuSO4, i.e., control, 0.28, 0.42, and 0.56 μgL−1. For comparative analysis of hematological and biochemical changes, blood/serum samples were obtained on 12, 24, and 36 days. Overall, the body weight of fish decreased with the time and dose of CuSO4; as the dose increases, body weight decreases. Dose and time-dependent results were observed in other parameters also. Results showed a significant increase in leukocytes, whereas red blood cells count, Hb, and Hct were significantly reduced in treated groups compared to the control. The mean corpuscular hemoglobin (MHC) and mean corpuscular hemoglobin concentration (MCHC) showed a non-significant decrease in treated groups compared to the control group. Serum biochemical parameters, including total proteins, albumin, and globulin, decreased significantly (p < 0.05). At the same time, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glucose, and cholesterol were significantly (p < 0.05) increased in the treated groups compared to the control group. Significantly (p < 0.05) increased levels of lipid peroxidation while decreased values of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (RGSH) in the blood of fish were recorded. Histopathological examination of fish gills, liver, and kidneys showed inflammation and degenerative changes due to CuSO4 exposure. In the brain tissue, degenerative changes like neuron necrosis, intracellular edema, cytoplasmic vacuolization, and congestion were observed. In conclusion, the study indicates that exposure to copper sulfate, even in smaller concentrations, can cause adverse hematological and histopathological changes in L. rohita fish.

show abstract

Evaluation of Effects of Titanium Dioxide and Zinc Oxide Nanoparticles on Baker’s Yeast (Saccharomyces cerevisiae) Glutathione Reductase Activities

Karadag

Atkan²

2022

Bull Environ Contam Toxicol

View full text Add to dashboard Cite

An Investigation on Freshwater Fish Oreochromis niloticus (Linnaeus, 1758): Assessing Hemotoxic Effects of Different Copper Compounds Used as Nanomaterial or Pesticide

Cited by 4 publications

References 26 publications

Is the trend toward a sustainable green synthesis of copper oxide nanoparticles completely safe for Oreochromis niloticus when compared to chemical ones?: using oxidative stress, bioaccumulation, and histological biomarkers

Is the trend toward a sustainable green synthesis of copper oxide nanoparticles completely safe for Oreochromis niloticus when compared to chemical ones?: using oxidative stress, bioaccumulation, and histological biomarkers

Copper sulfate induces clinico-hematological, oxidative stress, serum biochemical and histopathological changes in freshwater fish rohu (Labeo rohita)

Evaluation of Effects of Titanium Dioxide and Zinc Oxide Nanoparticles on Baker’s Yeast (Saccharomyces cerevisiae) Glutathione Reductase Activities

Contact Info

Product

Resources

About