An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population

Tencomnao, Tewin; Wongpiyabovorn, Jongkonnee

doi:10.4238/vol9-4gmr920

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…Serotonin may be triggered psoriasis as a growth factor that promotes keratinocyte proliferation [139]. The serotonin transporter gene promoter region and serotonin2A receptor gene have been found associated with psoriasis in Thai population [140,141].…”

Section: Psychological Trauma and Addictionmentioning

confidence: 99%

Psoriasis and Genetics

Merve¹,

Sevilay²,

Oymak³

et al. 2017

An Interdisciplinary Approach to Psoriasis

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Psoriasis is an erythematous, scaly chronic inflammatory dermatosis and occurs due to altered epidermal differentiation and hyperproliferation due to faulty signals that speed up the growth cycle of skin cells. Psoriasis reduces quality of life, and psoriatic patients generally have higher risk for metabolic disease. Psoriasis is associated with many burdening comorbidities, which often share similar pathogenic features and follow a progressive pattern. Genetic variation in human genome causes specific kind of disease, and nowadays, research is focused on metabolic pathways that trigger psoriasis and related comorbidities. In addition, genetic variations are also important for psoriasis treatment regime and response. The purpose of this section is to shown to genetic epidemiology, pharmacogenetics, immune genetics of psoriasis and related comorbidities.

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Section: Psychological Trauma and Addictionmentioning

confidence: 99%

Psoriasis and Genetics

Merve¹,

Sevilay²,

Oymak³

et al. 2017

An Interdisciplinary Approach to Psoriasis

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show abstract

“…It is known that the amount of serotonin in patients’ platelets is low. [11] However, the expression of the 5HT2A receptor in psoriatic skin is significantly elevated. [12] The polymorphism rs6311 of the HT2A gene, which is located in the binding region of the Th1/E47 transcription factor, has been associated with late onset of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Investigation of immunovascular polymorphisms and intersections in psoriasis

Urganci

Açıkbaş

2019

Indian J Dermatol

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Background: Psoriasis is a chronic, inflammatory skin disease. The etiology of the disease is unknown. It is a polygenic and multifactorial disease, which interacts with genetic and environmental factors. Genetic factors (polymorphism/mutation) can alter the immune system and normal physiologically functioning keratinocytes to pathological or predisposition levels. Aims: We aimed to investigate psoriasis at a different and novel window by searching for vascular and immunological variations and intersections in psoriasis. We investigated the main vascular and hypoxic controlling factors, which are vascular endothelial growth factor (VEGF) and hypoxia inducible factor 1 alpha (HIF-1α), as well as immunological and serotonergic factors, such as TNF-α, IL-10, and 5HT2A, which could connect each other to the pathogenesis of psoriasis. Subjects and Methods: Nine single nucleotide polymorphisms (SNPs) in five genes were genotyped by mini-array format in 300 subjects: VEGF (rs2010963, rs833061, and rs1570360), HIF-1α (rs11549465), TNF-α (rs361525, rs1799964, and rs1800629), IL-10 (rs1800896), and 5HT2A (rs6311). Results: An association was found between rs1800629 (TNF-α) and Type I psoriasis, and rs833061 (VEGF) and Type II psoriasis. Haplotype analysis suggests that the coexistence of the polymorphisms rs1799964 (TNF-α), rs2010963 (VEGF), rs833061 (VEGF), and rs6311 (5HT2A) may be a protective factor for psoriasis. Conclusion: Our results suggest that the vascular component of the studied vasculo-immunologic variation is more relevant in the pathogenesis of psoriasis.

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Behavioural Genetics of the Serotonin Transporter

Haddley

Bubb

Breen

et al. 2011

Current Topics in Behavioral Neurosciences

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The serotonin transporter is a key regulator of the bioavailability of serotonin and therefore any modulation in the expression or action of the transporter would be expected to have consequences on behaviour. The transporter has therefore become a target for pharmaceutical intervention in behavioural and mood disorders. The search for polymorphic variants in the transporter that would associate with neurological disorders has been extensive but has become focused on two domains which are both termed variable number tandem repeat (VNTR)polymorphisms. Both of these VNTRs are in non-coding DNA and therefore proposed to be mechanistically involved in a disorder through their ability to modulate transcriptional or post-transcriptional regulation of the transporter. The most extensively studied is in the promoter and is a bi-allelic insertion/deletion found in the 50 promoter region of the gene 1.2 kb upstream of the transcriptional start site. This VNTR, termed, 5-HTTLPR was initially identified as two variants containing either, 14 (short/deletion) or 16 (long/insertion) copies of a 22 bp repeat. A second widely studied VNTR found in the non-coding region of the transporter is located within intron 2 and comprises 9, 10 or 12 copies of a16–17 bp repeat termed, STin2.9, STin2.10 and STin2.12, respectively. These VNTR polymorphisms have been associated with a range of behavioural and psychiatric disorders including depression, OCD, anxiety and schizophrenia, however often the lack of reproducibility in different cohorts has led to debate on the actual association of the polymorphisms with this extensive range of neurological conditions. Here we review these two polymorphic VNTRs in depth and relate that to pharmaceutical response, their ability to regulate differential transporter expression, their core involvement in gene-environment interaction and their genetic association with specific disorders.

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An investigation of the relationship between serotonin transporter gene promoter polymorphism and psoriasis susceptibility in a Thai population

Cited by 7 publications

References 35 publications

Psoriasis and Genetics

Psoriasis and Genetics

Investigation of immunovascular polymorphisms and intersections in psoriasis

Behavioural Genetics of the Serotonin Transporter

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