An Investigation of the Mechanisms Underlying the Disparity Between Rate of Residual Endocervical Adenocarcinoma In Situ (AIS) in Hysterectomy Specimens and Clinical Failure Rate Following Conservatively Treated AIS
Abstract:The location, amount, and anatomic relationships of adenocarcinoma in situ (AIS) in 5 delayed second cone biopsy excision specimens and 21 definitive-therapy hysterectomy specimens were measured in relation to the neosquamocolumnar junction (nSCJ). All 5 biopsy specimens had 1 to 2 mm of AIS situated at the nSCJ. None had AIS in the proximal endocervix, despite positive or extremely close biopsy margins. Residual AIS in hysterectomy specimens was located proximal to the nSCJ in 19 (90%) of 21 cases. The mean d… Show more
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