An investigation of the long-term bioactivity of endogenous growth factor in OASIS Wound Matrix

Hodde, Jason P.; Ernst, David M.J.; Hiles, Michael C.

doi:10.12968/jowc.2005.14.1.26721

Cited by 136 publications

(74 citation statements)

References 15 publications

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“…21,37,38 Degradationdependent events such as the release of constituent growth factors, the production and release of matricryptic peptides, and the recruitment of host progenitor cells and stem cells contribute to the well-documented dynamic histomorphologic changes that characterize the host response to such scaffold materials during this early postoperative period. 3,4,6,9,12,[39][40][41][42][43] It is logical to speculate, based upon the results of the present study, that blood-derived mononuclear macrophages are at least important, if not essential, mediators of these degradation-dependent events. It is therefore reasonable to conclude that the degradation of an ECM scaffold is beneficial and necessary to tissue remodeling efforts.…”

Section: Discussionmentioning

confidence: 70%

Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds

Valentin

Stewart‐Akers

Gilbert

et al. 2009

Tissue Engineering Part A

307

254

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Biologic scaffolds composed of extracellular matrix (ECM) are widely used to facilitate remodeling and reconstruction of a variety of tissues in both preclinical animal studies and human clinical applications. The mechanisms by which such scaffolds influence the host tissue response are only partially understood, but it is logical that the mononuclear macrophage cell population plays a central role. The present study evaluated the role of macrophages that derive from peripheral blood in the degradation of ECM scaffolds. An established rat body wall reconstruction model was used to evaluate the degradation of carbodiimide (CDI)-crosslinked scaffolds composed of porcine small intestinal submucosa (SIS), noncrosslinked SIS, and autologous body wall. To assess the role of circulating macrophages in the degradation process, the degradation of each scaffold was assessed with and without macrophage depletion caused by administration of clodronate-containing liposomes. Results showed that peripheral blood monocytes are required for the early and rapid degradation of both SIS scaffolds and autologous body wall, and that CDI crosslinked SIS is resistant to macrophage-mediated degradation.

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Section: Discussionmentioning

confidence: 70%

Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds

Valentin

Stewart‐Akers

Gilbert

et al. 2009

Tissue Engineering Part A

307

254

View full text Add to dashboard Cite

show abstract

“…SIS is mainly composed of collagen type 1 and contains endogenous growth factors such as FGF and TGF-b and other chemoattractants. [17][18][19] Several studies have shown that SIS can provide a collagenous matrix to promote cell migration into the healing site to enhance revascularization and repair. [20][21][22][23][24] It is hypothesized that SIS enhance and promote the healing of the ACL.…”

Section: Introductionmentioning

confidence: 99%

Healing of the Goat Anterior Cruciate Ligament After a New Suture Repair Technique and Bioscaffold Treatment

Nguyen

Geel

Schulze

et al. 2013

Tissue Engineering Part A

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Primary suture repair of the anterior cruciate ligament (ACL) has been used clinically in an attempt to heal the ruptured ACL. The results, however, were not satisfactory, which in retrospect can be attributed to the used suturing technique and the suboptimal healing conditions. These constraining conditions can be improved by introducing a new suturing technique and by using small intestinal submucosa (SIS) as a bioscaffold. It is hypothesized that the suturing technique keep the torn ends together and that SIS enhance and promote the healing of the ACL. The goat was used as the study model. In the Suture group, the left ACL was transected and suture repaired with a new locking suture repair technique (n = 5) allowing approximation and fixation under tension. The Suture-SIS group underwent the same procedure with the addition of SIS (n = 5). The right ACL served as control. After 12 weeks of healing, anterior-posterior translation and in situ force of the healing ACL were measured, followed by the measurement of the cross-sectional area and structural stiffness. Routine histology was performed on tissue samples. Gross morphology showed that the healing ACL was continuous with collagenous tissue in both groups. The cross-sectional area of the Suture and the Suture-SIS group was 35% and 50% of the intact control, respectively. The anterior-posterior translations at different flexion angles were statistically not different between the Suture group and the Suture-SIS group. Only the in situ force at 30°in the Suture-SIS group was higher than in the Suture group. Tensile tests showed that the stiffness for the Suture group was not different from the Suture-SIS group (31.1 -8.1 N/mm vs. 41.9 -18.0 N/mm [p > 0.05]). Histology showed longitudinally aligned collagen fibers from origo to insertion. More fibroblasts were present in the healing tissue than in the control intact tissue. The study demonstrated the proof of concept of ACL repair in a goat model with a new suture technique and SIS. The mechanical outcome is not worse than previously reported for ACL reconstruction. In conclusion, the approach of using a new suture technique, with or without a bioscaffold to heal the ACL is promising.

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“…Inflammation, the first phase of wound healing, features various members of the FGF family i.e. FGF-1, FGF-4, and FGF-2 [69][70][71]. These FGFs attract other immune cells to the site of inflammation, control the proliferation of platelets since they have significant activity at inflammation sites [72].…”

Section: Fgfs and Fgfrs: Roles In Biological Processesmentioning

confidence: 99%

Fibroblast Growth Factors and their Emerging Cancer-Related Aspects

Khalid¹,

Javaid²

2016

J Cancer Sci Ther

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An investigation of the long-term bioactivity of endogenous growth factor in OASIS Wound Matrix

Cited by 136 publications

References 15 publications

Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds

Macrophage Participation in the Degradation and Remodeling of Extracellular Matrix Scaffolds

Healing of the Goat Anterior Cruciate Ligament After a New Suture Repair Technique and Bioscaffold Treatment

Fibroblast Growth Factors and their Emerging Cancer-Related Aspects

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